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Pioneering high-quality bioprocessing filtration solutions

As you adjust to the increasing demands for volume, customization, speed to market and scalability in the biopharmaceutical industry, Solventum is here to help. We partner with you, deploying cutting-edge, sustainable technologies in filtration, clarification and purification to simplify your bioprocessing filtration needs. 

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An uncompromising commitment to quality, efficiency and sustainability

Navigating biopharmaceutical purification processes can be challenging. Whether for clinical trials or accelerating life-saving drugs to market, you want to deliver solutions in a sustainable manner, balance costs and comply with regulatory requirements — all at the same time. That’s why we’re dedicated to innovation across our portfolio of purification solutions built to address your complex bioprocess challenges. By intensifying unit operations and reducing unnecessary consumables and waste, our solutions can help you optimize your process efficiencies. And they’re designed to deliver high-quality and cost-effective biopharmaceutical output that safeguards molecule integrity and facilitates process scalability. 

Btec photoshoot 3M™ Harvest RC lab worker connecting capsules - 13

Advanced technology solutions in bioprocessing purification

Partnering to enhance your bioprocessing operations 

Monoclonal antibody (mAb) and recombinant protein manufacturing

In monoclonal antibody (mAb) and recombinant protein manufacturing, achieving optimal product yield and quality while managing costs can be challenging. At Solventum, we understand these demands and offer a wide range of solutions to meet your unique needs for efficient and effective impurity removal in the mAb and recombinant protein manufacturing production process, a critical element across all of our bioprocessing solutions.

Our cutting-edge technologies are designed to enhance your production processes, ensuring efficient impurity removal and upgrading filtrate quality. The 3M™ Harvest RC Chromatographic Clarifier platform is a high-capacity, synthetic, single-use clarification platform that includes both a direct clarification solution and a centrate clarification solution. The 3M™ Zeta Plus™ Depth Filters, 3M™ Emphaze™ AEX Hybrid Purifier and 3M™ Polisher ST dovetail into your current processes at specific stages.

Btec photoshoot 3M™ Harvest RC Centrate lab workers setting up equipment - 119

Gene therapy

In the rapidly evolving field of gene therapy, the challenges of ensuring efficiency, safety and scalability are ever-present. As our understanding of cell biology advances, vector-directed gene therapy is gaining ground as a significant future drug modality. As demand grows for this life-transforming therapy, our innovative solutions may help you deliver high quality drug substances.  

Our bioprocessing filtration and purification products can be integrated into your manufacturing processes for gene therapy drug products that utilize AAVs as viral vectors, similar to the production of recombinant protein therapies. We offer innovative clarification methods that separate based on charge, rather than particle size, removing large contaminants like cells and cell debris as well as smaller impurities like DNA and HCP.  

Medical Research Laboratory: Portrait of Female Scientist Working on Computer, Analysing DNA, Virus.

Plasma-derived therapies

Our products and solutions are used to create a range of life-saving therapies during plasma fractionation and purification—the critical process that involves separating various components of blood plasma. Solventum’s solutions are designed to meet your needs across a range of plasma-derived therapy manufacturing. 3M™ Zeta Plus™ Depth Filters are available in three formats: sheets, cartridges and capsules, with the right media and pore sizes to help you get the job done. 3M™ Zeta Plus™ Encapsulated System Filter Capsules can fulfill your depth filtration needs in an easy-to-use format.  

Sterile filtration is a critical step in the highly controlled environment of plasma processes. Our 3M™ LifeASSURE™ PDA Series Filter portfolio comes with advanced pleat technology to increase the effective filtration area.

Hands in blue medical gloves hold a tripod with test tubes with blood samples. Blood is divided into fractions. Plasma of blood. In the background is a centrifuge.

Vaccine therapy

Managing purification and clarification as you scale your vaccine production can be complex while maintaining efficiency and yield. We provide a range of solutions that cater to your needs to improve clarification and desired purity and enable consistent product quality. Our 3M™ Harvest RC Chromatographic Clarifier platform and 3M™ Zeta Plus™ Encapsulated System Filter Capsules can be used from lab scale to commercial manufacturing, from discovery to production, to enable you to streamline processes and improve efficiency.  

To learn more about our vaccine applications, reach out to one of our experts.

Doctor gives vaccine

Chemical pharmaceuticals

Understanding the complexities of your chemical pharmaceutical manufacturing is important to us at Solventum. We provide you with filtration technologies for a wide range of applications including active pharmaceutical ingredient (API) manufacturing, across many stages of pharmaceutical processing and sterile filtration. Our membrane-based separations and depth filtration systems deliver optimal results to meet regulatory requirements.

Shot of Sterile Pharmaceutical Manufacturing Laboratory where Scientists in Protective Coverall's Do Quality Control

Let our specialists help you achieve your vision

When you’re developing a new biopharmaceutical product, you want to focus on bringing your solution to patients — and that takes solving challenges in research, development and manufacturing as soon as they arise. Our network of bioprocess application specialists can help you simplify your process and troubleshoot filtration issues, no matter where you are in your product journey or where you sit globally. With specialists in over 70 countries around the world, we provide you with access to the best support so we can share ideas and learn from each other. 

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Sustainability at Solventum

Solventum is prioritizing sustainability in our operations, supply chain and corporate culture, including reducing our own greenhouse gas emissions, energy and water use, and waste. Our solutions are designed to help you meet your sustainability goals. As part of this commitment, our single-use technologies in biopharmaceutical manufacturing intensify the process, using fewer steps and inputs, which may result in a smaller environmental footprint than traditional, reusable methods. 

Solutions like the 3M™ Harvest RC Chromatographic Clarifier help combine the traditional 3-step clarification process into a single, intensified unit operation for chromatographic separation, lowering pre-use flush volumes and improving output through higher mAb product recovery. In turn, this reduces the amount of water and energy consumed in this phase, when compared to traditional clarification methods or stainless steel facility setups.

Learn more about sustainability with our solutions

Learn more about process intensification

As members of the Bio-Process Systems Alliance, we share in their mission to facilitate the development and manufacturing of safe and sustainable single-use technologies. 

Process engineer in green lab coat looks at product

School of Purification: Start learning today

Developed by our global experts, passionate about innovative approaches to biopharmaceutical separation and purification, School of Purification provides resources to help you and your team ramp up quickly. These free webinars and on-demand learning resources cover overcoming bottlenecks, optimizing efficiency, current trends, and future possibilities.

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