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Take control of preoperative nasal decolonization

3M™ Skin and Nasal Antiseptic (Povidone-Iodine Solution 5% w/w [0.5% available iodine] USP) Patient Preoperative Skin Preparation is designed to reduce bacteria in the nares prior to surgery and help reduce risks of surgical site infections (SSIs) as part of a comprehensive preoperative protocol

 

 

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Enhance patient safety in the ICU and the OR

Nurse swabbing female patient's nose. Skin and nasal image.

Make Skin and Nasal Antiseptic part of your nasal decolonization protocol

 

Confidence in surgery matters. Take control of your patients’ nasal decolonization in both the intensive care unit (ICU) and operating room (OR) with Skin and Nasal Antiseptic.

 

Designed to help address the rising concern of SSIs that can be caused by bacteria in the nares, this solution is a key element of patient preoperative skin preparation. By reducing the risk factors that contribute to SSIs, you can make a significant impact on patient outcomes. Using Skin and Nasal Antiseptic helps reduce bacterial load, including Staphylococcus aureus, which is the leading cause of SSIs among adult and pediatric patients. By aligning with CDC, SHEA, IDSA, APIC and other leading organizations, you can help prevent SSIs.


 

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Proven efficacy. Simple application

Make a real difference in your presurgical infection prevention protocol with Skin and Nasal Antiseptic (Povidone-Iodine Solution 5% w/w [0.5% available iodine] USP) Patient Preoperative Skin Preparation. Designed to prepare the skin prior to surgery and help reduce bacteria that potentially can cause skin infection. 

Chart image comparing Solventum Skin and Nasal Antiseptic to other competitor products. Provides information across a list of attributes.
When it comes to nasal antiseptics, formulation matters

 

Not all nasal decolonization solutions are created equally. 3M™ Skin and Nasal Antiseptic includes a unique polymer for longer efficacy.

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3M Skin and Nasal Antiseptic Application
  • Simple, one-time application 
  • Reduces bacteria in the nares including S. aureus by 99.5% in just 1 hour and maintains reduction for at least 12 hours*1​
  • Reduces bacteria on the abdomen by 99.7% and groin by 99.9% within 10 minutes and maintains for at least 6 hours*2

 

*As demonstrated through in vivo testing; mean values

Proven performance

Improves patient safety and protocol compliance without antibiotics.3

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In a randomized trial, 3M Skin and Nasal Antiseptic demonstrated a significant reduction of S. aureus SSIs (zero infections) compared to mupirocin, when used as part of a comprehensive protocol.3​

An iconographic representation of a sick patient paired with a representation of bacteria. Dark green and medium teal positive color palette.

Unique film-forming polymer increases persistence. 

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Why choose Skin and Nasal Antiseptic?

Your patients are counting on you - be sure you're doing everything you can to help prevent surgical site infections (SSIs). With a simple one-time application,4 you'll be able to reduce bacterial counts in the nares, including Staphylococcus aureus.5 Get it right the first time, every time with 3M™ Skin and Nasal Antiseptic.

Remove the variables

Achieve greater compliance by eliminating patient inconsistency with an easy one-time application at your facility.8

Achieve cost-effective decolonization

Lower estimated median total product cost than other antiseptics.9

One-time application maintains effectiveness

Significantly reduce nasal bacterial counts, including S. aureus by 99.5%, and maintain that reduction for at least 12 hours with a one-time application.3,8

Extensively researched

3M™ Skin and Nasal Antiseptic has more than 10 published peer-reviewed and investigator-initiated studies and 20+ pieces of supporting evidence.3, 5-7, 10

Choose our evidence-based Skin and Nasal Antiseptic as part of your nasal decolonization protocol to prepare the skin prior to surgery and help reduce bacteria that potentially can cause skin infections.

Solventum Peak Decolonization

Our decolonization assessment program analyzes current practices at your facility, enabling you to implement evidence-based protocols that reduce the risk of SSIs and enhance surgical outcomes.

Learn more about Peak
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Contact a Solventum representative

We're here to help! Our team of representatives can provide you with information and resources to help you. Submit the form below to speak with a Solventum representative to learn more about your options.

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References:

  1. 3M study 05-011100​
  2. 3M study 05-010945​
  3. Phillips M, Rosenburg A, Shopsin B, et al. Preventing surgical site infections;​ A randomized, open-label trial of nasal mupirocin ointment and nasal povidone-iodine​ solution. Infect Control Hosp Epidemiol.2014;35:826-832.​
  4. (Ex vivo porcine model): Anderson M, et al. 2015. Efficacy of Skin and Nasal Povidone-Iodine Preparation against mupirocin resistant MRSA and Staphylococcus aureus with the anterior nares, Antimicrob Agents Chemother. 2015 May;59(5):2765-73 pii: AAC.04624-14​
  5. Bebko SP, Green DM, Awad SS. Effect of a preoperative decontamination protocol​ on surgical site infections in patients undergoing elective orthopedic surgery with​ hardware implantation. JAMA Surg. Published online March 04, 2015.doi:10.1001/jamasurg.2014.3480.​
  6. Urias DS, Varghese M, Simunich T, Morrissey S, Dumire R. Preoperative decolonization​ to reduce infections in urgent lower extremity repairs. European Journal of Trauma and​ Emergency Surgery. 2018:17. doi:10.1007/s00068-017-0896-1.​
  7. Loftus RW, Dexter F, Goodheart MJ, et al. The Effect of Improving Basic Preventive​ Measures in the Perioperative Area on Staphylococcus aureus Transmission and​ Surgical Site Infections: A Randomized Clinical Trial. JAMA Netw Open.2020; 3(3):​e201934. doi:10.1001/jamanetworkopen.2020.1934.​
  8. Solventum internal data on file.​
  9. Premier Market Insights, Premier Inc. 2025. Data on file. Based on ERP or transactional​ data from acute care facilities representing 25% of the entire U.S. acute care segment,​ data pulled 12/1/2024-12/31/2025.​
  10. Torres EG, Lindmair-Snell JM, Langan JW, Burnikel BG. Is preoperative nasal povidone-iodine as efficient and cost-effective as standard methicillin-resistant Staphylococcus aureus screening protocol in total joint arthroplasty? J Arthroplasty. 2016; 31:​215218.