Chromatographic capture of cells to achieve single stage clarification in recombinant protein purification
We explored the impact of a novel single use technology employing chromatographic principle-based clarification for a process-intensified cell line technology. In this study, a 16% economic benefit ($/g) was observed using a single-use chromatographic clarification compared to traditional single-use clarification technology by improving the overall product cost through decreased operational complexity, higher loading capacity, increased product recovery, and higher impurity clearance.
Seeking drug manufacturing platform - Can drug platforms keep up with complex new molecules?
As therapies have grown in complexity, some drug manufacturing platforms have lost viability. To address a variety of modalities while continuing to operate efficiently, it is necessary to reinvent how physics and chemistry are utilized within these separation technologies.
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Single-stage chromatographic clarification of Chinese Hamster Ovary cell harvest reduces cost of protein production
The use of the 3M™ Harvest RC Chromatographic Clarifier, a single-stage chromatographic clarification product, is identified as an alternative strategy to a three-stage filtration train. Using bioprocess cost modeling, the overall cost of the clarification process was reduced by 17%–30% through process compression, depending on bioreactor scale.