3M™ Harvest RC Chromatographic Clarifier
About the product
The 3M™ Harvest RC Chromatographic Clarifier is a single stage single-use chromatographic clarification solution designed as an efficient option for harvesting and clarification of modern cell cultures. Clarification with this chromatographic clarifier offers fewer processing steps, higher yield and lower production time and costs.
Product details
3M™ Harvest RC Chromatographic Clarifier
Single-stage chromatographic clarification for recombinant protein therapeutic manufacturing.
- Simplification of high cell density cell culture fluid clarification unit operations.
- Remove cells, cell debris and DNA (<500 ppb) from the harvested cell culture fluid.
- Optimized for PCV high density CHO cell culture (5-8% PCV)
- Replacement of primary, secondary and guard membrane clarification stages.
- Typical product recovery of 95+% (capsules)
- Synthetic chromatographic harvest media with chemically defined extractables.
- Predictable scaling from discovery to manufacturing.
- Lower total cost of manufacturing compared to centrifugation and depth filtration.
- Lower consumption of buffer and water compared to depth filtration.
- Capsules fit into laboratory to manufacturing scale workflows.
Suggested Applications
- Biopharmaceutical processing applications of aqueous based pharmaceutical (drugs) and vaccines in accordance with the product instructions and specifications, and cGMP requirements (for BC340, BC1020, BC2300 and BC16000) or GLP requirements (for CT15, WP6, BC4, BC25 and BT500), where applicable.
Product specifications
| Industries |
Industries
Biopharmaceutical manufacturing |
| Category Name |
Category Name
Chromatography Filters |
| Net Weight (Metric) |
Net Weight (Metric)
75.8 g, 3.4 kg, 9.8 kg, 1.1 kg, 1.6 kg, 69.2 g, 14.3 g |
| Filter Technology |
Filter Technology
Anion exchange chromatography |
| Micron Rating |
Micron Rating
0.2 μm |
| Product Series |
Product Series
Harvest RC |
| Flow Rate (Metric) |
Flow Rate (Metric)
4.2 ml/min, 380 ml/min, 2.7 l/min, 57 ml/min, 170 ml/min, 0.53 ml/min |
| Flow Rate (Imperial) |
Flow Rate (Imperial)
0.001 gal/min, 0.084 gal/min, 0.594 gal/min, 0.013 gal/min, 0.037 gal/min, 0 gal/min |
| Overall Height (Imperial) |
Overall Height (Imperial)
6.34 in, 3.39 in, 2.24 in, 7.99 in, 4.09 in, 5.98 in, 2.09 in, 2.4 in, 3.5 in, 2.32 in |
| Overall Diameter (Imperial) |
Overall Diameter (Imperial)
4.37 in, 3.03 in, 17.8 in, 9.49 in, 1.14 in, 1.69 in |
| Overall Length (Imperial) |
Overall Length (Imperial)
5 in |
| Overall Width (Metric) |
Overall Width (Metric)
8.6 cm |
| Overall Length (Metric) |
Overall Length (Metric)
12.7 cm |
| Overall Diameter (Metric) |
Overall Diameter (Metric)
111 mm, 7.7 cm, 45.2 cm, 24.1 cm, 2.9 cm, 4.3 cm |
| End Modification |
End Modification
3/4" Sanitary, 1-1/2" Sanitary, Luer-Lok, Non Pertinent |
| Filter Type |
Filter Type
Single Use |
| Overall Width (Imperial) |
Overall Width (Imperial)
3.39 in |
| Application |
Application
Harvest and clarification |
| Overall Height (Metric) |
Overall Height (Metric)
161 mm, 8.6 cm, 5.7 cm, 20.3 cm, 10.4 cm, 15.2 cm, 5.3 cm, 6.1 cm, 8.9 cm, 5.9 cm |
