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3M™ Harvest RC Centrate Chromatographic Clarifier

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3M™ Harvest RC Centrate Chromatographic Clarifier
(4) Harvest RC: Simpler process procedure compared to traditional lab approaches
2 - Dedicated Faucet Water Filter: 3M Aqua-Pure™ Under Sink Dedicated Faucet Water Filter System
1 - Dedicated Faucet Water Filter: under sink filtration for cleaner, clearer, better tasting water
3 - Dedicated Faucet Water Filter: Fast, easy and clean filter change-outs
3M™ Aqua-Pure™ Under Sink Dedicated Faucet Water Filtration System, 04-99534, 0.5 um
(5) Harvest RC Chromatographic Clarifier: High quality samples in less than 10 minutes*
4 - Dedicated Faucet Water Filter: Easy installation
(3) Harvest RC Chromatographic Clarifier: Efficient workflows excellent clarity
5 - Dedicated Faucet Water Filter: Additional tools needed
(1) Harvest RC Chromatographic Clarifier: Predictable scaling from discovery to manufacturing
(2) Harvest RC Chromatographic Clarifier: Single-step cell culture for high recovery

About the product

Designed to effectively clarify Chinese Hamster Ovary (CHO) cell culture centrates produced by conventional and single-use conical plate (e.g., disc stack) centrifuges, 3M™ Harvest RC Centrate Chromatographic Clarifier is a single-stage chromatography solution that employs a synthetic fibrous anion exchange (AEX) Q-functional chromatography media to enable product recoveries of >95% and cell shear-related impurity reduction.

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1-5 of 10 Products

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Product name and IDs 3M ID Overall Width (Imperial) Overall Length (Imperial) Overall Length (Metric) Overall Width (Metric) Overall Diameter (Imperial) Overall Diameter (Metric) End Modification Micron Rating Flow Rate (Imperial) Overall Height (Imperial) Overall Height (Metric) Flow Rate (Metric) Filter Type Net Weight (Metric) Application Filter Technology Industries Product Series

3M ID

7100302871

Overall Width (Imperial)

-

Overall Length (Imperial)

-

Overall Length (Metric)

-

Overall Width (Metric)

-

Overall Diameter (Imperial)

4.3700 INCH

Overall Diameter (Metric)

111.0000 MILLIMETER

End Modification

-

Micron Rating

-

Flow Rate (Imperial)

-

Overall Height (Imperial)

6.3400 INCH

Overall Height (Metric)

161.0000 MILLIMETER

Flow Rate (Metric)

-

Filter Type

-

Net Weight (Metric)

-

Application

Harvest and clarification

Filter Technology

-

Industries

Biopharmaceutical manufacturing

Product Series

Harvest RC

3M ID

7100245350

Overall Width (Imperial)

-

Overall Length (Imperial)

-

Overall Length (Metric)

-

Overall Width (Metric)

-

Overall Diameter (Imperial)

1.1400 INCH

Overall Diameter (Metric)

2.9000 CENTIMETER

End Modification

Non Pertinent

Micron Rating

0.2000 MICROMETER

Flow Rate (Imperial)

-

Overall Height (Imperial)

2.4000 INCH

Overall Height (Metric)

6.1000 CENTIMETER

Flow Rate (Metric)

-

Filter Type

Single Use

Net Weight (Metric)

-

Application

Harvest and clarification

Filter Technology

Anion exchange chromatography

Industries

Biopharmaceutical manufacturing

Product Series

Harvest RC

3M ID

7100242700

Overall Width (Imperial)

3.3900 INCH

Overall Length (Imperial)

5.0000 INCH

Overall Length (Metric)

12.7000 CENTIMETER

Overall Width (Metric)

8.6000 CENTIMETER

Overall Diameter (Imperial)

-

Overall Diameter (Metric)

-

End Modification

Non Pertinent

Micron Rating

0.2000 MICROMETER

Flow Rate (Imperial)

-

Overall Height (Imperial)

3.5000 INCH

Overall Height (Metric)

8.9000 CENTIMETER

Flow Rate (Metric)

-

Filter Type

Single Use

Net Weight (Metric)

-

Application

Harvest and clarification

Filter Technology

Anion exchange chromatography

Industries

Biopharmaceutical manufacturing

Product Series

Harvest RC

3M ID

7100241969

Overall Width (Imperial)

-

Overall Length (Imperial)

-

Overall Length (Metric)

-

Overall Width (Metric)

-

Overall Diameter (Imperial)

1.6900 INCH

Overall Diameter (Metric)

4.3000 CENTIMETER

End Modification

Luer-Lok

Micron Rating

0.2000 MICROMETER

Flow Rate (Imperial)

0.0000 GALLON_PER_MINUTE

Overall Height (Imperial)

2.3200 INCH

Overall Height (Metric)

5.9000 CENTIMETER

Flow Rate (Metric)

0.5300 MILLILITER_PER_MINUTE

Filter Type

Single Use

Net Weight (Metric)

14.3000 GRAM

Application

Harvest and clarification

Filter Technology

Anion exchange chromatography

Industries

Biopharmaceutical manufacturing

Product Series

Harvest RC

3M ID

7100236867

Overall Width (Imperial)

-

Overall Length (Imperial)

-

Overall Length (Metric)

-

Overall Width (Metric)

-

Overall Diameter (Imperial)

3.0300 INCH

Overall Diameter (Metric)

7.7000 CENTIMETER

End Modification

3/4" Sanitary

Micron Rating

0.2000 MICROMETER

Flow Rate (Imperial)

0.0010 GALLON_PER_MINUTE

Overall Height (Imperial)

3.3900 INCH

Overall Height (Metric)

8.6000 CENTIMETER

Flow Rate (Metric)

4.2000 MILLILITER_PER_MINUTE

Filter Type

Single Use

Net Weight (Metric)

75.8000 GRAM

Application

Harvest and clarification

Filter Technology

Anion exchange chromatography

Industries

Biopharmaceutical manufacturing

Product Series

Harvest RC

3M ID

7100236866

Overall Width (Imperial)

-

Overall Length (Imperial)

-

Overall Length (Metric)

-

Overall Width (Metric)

-

Overall Diameter (Imperial)

9.4900 INCH

Overall Diameter (Metric)

24.1000 CENTIMETER

End Modification

3/4" Sanitary

Micron Rating

0.2000 MICROMETER

Flow Rate (Imperial)

0.0370 GALLON_PER_MINUTE

Overall Height (Imperial)

5.9800 INCH

Overall Height (Metric)

15.2000 CENTIMETER

Flow Rate (Metric)

170.0000 MILLILITER_PER_MINUTE

Filter Type

Single Use

Net Weight (Metric)

1.6000 KILOGRAM

Application

Harvest and clarification

Filter Technology

Anion exchange chromatography

Industries

Biopharmaceutical manufacturing

Product Series

Harvest RC

3M ID

7100236865

Overall Width (Imperial)

-

Overall Length (Imperial)

-

Overall Length (Metric)

-

Overall Width (Metric)

-

Overall Diameter (Imperial)

9.4900 INCH

Overall Diameter (Metric)

24.1000 CENTIMETER

End Modification

3/4" Sanitary

Micron Rating

0.2000 MICROMETER

Flow Rate (Imperial)

0.0130 GALLON_PER_MINUTE

Overall Height (Imperial)

4.0900 INCH

Overall Height (Metric)

10.4000 CENTIMETER

Flow Rate (Metric)

57.0000 MILLILITER_PER_MINUTE

Filter Type

Single Use

Net Weight (Metric)

1.1000 KILOGRAM

Application

Harvest and clarification

Filter Technology

Anion exchange chromatography

Industries

Biopharmaceutical manufacturing

Product Series

Harvest RC

3M ID

7100236863

Overall Width (Imperial)

-

Overall Length (Imperial)

-

Overall Length (Metric)

-

Overall Width (Metric)

-

Overall Diameter (Imperial)

3.0300 INCH

Overall Diameter (Metric)

7.7000 CENTIMETER

End Modification

Luer-Lok

Micron Rating

0.2000 MICROMETER

Flow Rate (Imperial)

0.0010 GALLON_PER_MINUTE

Overall Height (Imperial)

2.0900 INCH

Overall Height (Metric)

5.3000 CENTIMETER

Flow Rate (Metric)

4.2000 MILLILITER_PER_MINUTE

Filter Type

Single Use

Net Weight (Metric)

69.2000 GRAM

Application

Harvest and clarification

Filter Technology

Anion exchange chromatography

Industries

Biopharmaceutical manufacturing

Product Series

Harvest RC

3M ID

7100236846

Overall Width (Imperial)

-

Overall Length (Imperial)

-

Overall Length (Metric)

-

Overall Width (Metric)

-

Overall Diameter (Imperial)

17.8000 INCH

Overall Diameter (Metric)

45.2000 CENTIMETER

End Modification

1-1/2" Sanitary

Micron Rating

0.2000 MICROMETER

Flow Rate (Imperial)

0.5940 GALLON_PER_MINUTE

Overall Height (Imperial)

7.9900 INCH

Overall Height (Metric)

20.3000 CENTIMETER

Flow Rate (Metric)

2.7000 LITER_PER_MINUTE

Filter Type

Single Use

Net Weight (Metric)

9.8000 KILOGRAM

Application

Harvest and clarification

Filter Technology

Anion exchange chromatography

Industries

Biopharmaceutical manufacturing

Product Series

Harvest RC

3M ID

7100236845

Overall Width (Imperial)

-

Overall Length (Imperial)

-

Overall Length (Metric)

-

Overall Width (Metric)

-

Overall Diameter (Imperial)

17.8000 INCH

Overall Diameter (Metric)

45.2000 CENTIMETER

End Modification

1-1/2" Sanitary

Micron Rating

0.2000 MICROMETER

Flow Rate (Imperial)

0.0840 GALLON_PER_MINUTE

Overall Height (Imperial)

2.2400 INCH

Overall Height (Metric)

5.7000 CENTIMETER

Flow Rate (Metric)

380.0000 MILLILITER_PER_MINUTE

Filter Type

Single Use

Net Weight (Metric)

3.4000 KILOGRAM

Application

Harvest and clarification

Filter Technology

Anion exchange chromatography

Industries

Biopharmaceutical manufacturing

Product Series

Harvest RC

Product Details

Single-stage chromatographic clarification for centrate in recombinant protein therapeutic manufacturing

Single-stage chromatographic clarification for centrate in recombinant protein therapeutic manufacturing
3M™ Harvest RC Centrate Chromatographic Clarifier encapsulates innovative synthetic fibrous AEX Q-functional chromatography media combined with an asymmetric Q-functional polyamide membrane with a 0.2 µm qualifying zone. This enables effective single-stage clarification of CHO cell culture centrates produced by conventional and single-use conical plate (e.g., disc stack) centrifuges. Electrostatic interactions with a positively charged ligand immobilized on a fiber matrix and a downstream polyamide membrane capture soluble and insoluble impurities, resulting in efficient retention of a wide range of particles that have not been effectively separated by centrifugation or are produced by cell shear during centrifugation. Specifically, the AEX mechanism enables efficient capture of impurities <0.5 µm that are difficult to capture with traditional depth filtration and membrane filtration.
Cleaner centrate for an improved downstream process
mAb product recovery

mAb product recovery

The innovative 3M™ Harvest RC Centrate Chromatographic Clarifier effectively clarifies CHO cell culture centrates produced by conventional and single-use conical plate (e.g., disc stack) centrifuges. The single-mode electrostatic separation mechanism and high throughput media enables product recoveries of >95%

Cell shear-related impurity reduction

Cell shear-related impurity reduction

Achieve high quality and consistent clarified centrate using 3M™ Harvest RC Centrate Chromatographic Clarifier for CHO cell culture centrate. The clarified centrate has low turbidity (<15 NTU), low DNA (< 500 ppb) and the ability to protect a downstream sterile filter (>500 L/m2 for 0.1 μm filter).

Scalability

Scalability

From lab to manufacturing scale devices, 3M™ Harvest RC Centrate Chromatographic Clarifier provides a predictable and scalable solution aligned to process workflows.

The innovative synthetic fibrous AEX chromatographic clarification media enables a single-stage centrate clarification from CHO cell cultures with high product recovery and high fidelity of soluble and insoluble impurity removal. The 0.2 µm asymmetric Q-functional polyamide membrane, which is downstream of the fibrous chromatographic clarification media, distributes the flow across the AEX media bed and enables the protection of the downstream sterilizing grade membrane filter. Also, the 0.2 µm functionalized polyamide membrane enables simple process endpoint measurement using pressure reading.
Clarify centrate like never before
Separation by charge

Separation by charge

Consisting of a range of high-capacity, single-use synthetic chromatographic clarification products that separate by charge, the 3M™ Harvest RC Centrate Chromatographic Clarifier product family was designed with a fiber chromatography media to effectively capture cell shear-related insoluble impurities in the submicron size range that are typically present in centrate feed streams.

Particle size control

Particle size control

3M™ Harvest RC Centrate Chromatographic Clarifier provides effective reduction of a wide range of particle sizes that are typically present in centrate feed streams. The fiber chromatography technology is highly effective at capturing the population of <0.5 µm particles that are difficult to remove using traditional depth filtration.

Robust sterile membrane filter protection

Robust sterile membrane filter protection

Due to the highly effective chromatographic reduction of soluble and insoluble impurities, 3M™ Harvest RC Centrate Chromatographic Clarifier enables efficient centrate clarification. This allows the effective protection of the final sterilizing grade membrane filter down to 0.1 µm pore size.

Resisting clarification stage particle breakthrough

Resisting clarification stage particle breakthrough

The Q-functionalized fibrous media and membrane of the 3M™ Harvest RC Centrate Chromatographic Clarifier can prevent particle breakthrough, which can impact membrane filter performance. With wet-laid media present in depth filters, particle breakthrough can occur, creating pressure buildup across the membrane filter stage, which destabilizes the clarification process.

    • Single-stage centrate clarification for process compression and streamlining of process development.
    • Enables de-risking of clarification process development, scale-up and tech transfer for faster speed to market.
    • Synthetic, functionalized fibrous media provides effective soluble impurity removal in centrate, including DNA and cell shear-related submicron particle reduction.
    • Predictable performance scalability for consistent centrate clarification at various process scales.
    • tThe single-mode electrostatic separation mechanism and high-throughput media enable product recoveries of >95%.
    • Provides comparable effluent quality to 3M™ Harvest RC Chromatographic Clarifier for a modern clarification platform.
    • tLower consumption of buffer or water compared to depth filtration.
    • tAlkaline-resistant capsules for pre-use sanitization.

Suggested Applications

    • BC4, BC25, BC170, BC340, BC1020, BC2300 and BC18400: Biopharmaceutical processing applications of aqueous-based pharmaceuticals (drugs) and vaccines in accordance with the product instructions and specifications, cGMP and GLP requirements, where applicable.

Product Specifications

Industries
Industries

BiopharmaceuticalManufacturing

Net Weight (Metric)
Net Weight (Metric)

1.1000, 1.6000, 14.3000, 3.4000, 69.2000, 75.8000, 9.8000

Filter Technology
Filter Technology

Anion exchange chromatography

Micron Rating
Micron Rating

0.2000

Product Series
Product Series

Harvest RC

Flow Rate (Metric)
Flow Rate (Metric)

4.2000, 0.5300, 170.0000, 2.7000, 380.0000, 57.0000

Flow Rate (Imperial)
Flow Rate (Imperial)

0.0010, 0.0000, 0.0130, 0.0370, 0.0840, 0.5940

Overall Height (Imperial)
Overall Height (Imperial)

2.0900, 2.2400, 2.3200, 2.4000, 3.3900, 3.5000, 4.0900, 5.9800, 6.3400, 7.9900

Overall Length (Imperial)
Overall Length (Imperial)

5.0000

Overall Diameter (Imperial)
Overall Diameter (Imperial)

17.8000, 3.0300, 9.4900, 1.1400, 1.6900, 4.3700

Overall Width (Metric)
Overall Width (Metric)

8.6000

Overall Length (Metric)
Overall Length (Metric)

12.7000

Overall Diameter (Metric)
Overall Diameter (Metric)

24.1000, 45.2000, 7.7000, 111.0000, 2.9000, 4.3000

End Modification
End Modification

3/4" Sanitary, 1-1/2" Sanitary, Luer-Lok, Non Pertinent

Filter Type
Filter Type

Single Use

Overall Width (Imperial)
Overall Width (Imperial)

3.3900

Application
Application

HarvestAndClarification

Overall Height (Metric)
Overall Height (Metric)

10.4000, 15.2000, 161.0000, 20.3000, 5.3000, 5.7000, 5.9000, 6.1000, 8.6000, 8.9000

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