3M™ Harvest RC Centrate Chromatographic Clarifier
About the product
Designed to effectively clarify Chinese Hamster Ovary (CHO) cell culture centrates produced by conventional and single-use conical plate (e.g., disc stack) centrifuges, 3M™ Harvest RC Centrate Chromatographic Clarifier is a single-stage chromatography solution that employs a synthetic fibrous anion exchange (AEX) Q-functional chromatography media to enable product recoveries of >95% and cell shear-related impurity reduction.
Product details
Single-stage chromatographic clarification for centrate in recombinant protein therapeutic manufacturing
- Single-stage centrate clarification for process compression and streamlining of process development.
- Enables de-risking of clarification process development, scale-up and tech transfer for faster speed to market.
- Synthetic, functionalized fibrous media provides effective soluble impurity removal in centrate, including DNA and cell shear-related submicron particle reduction.
- Predictable performance scalability for consistent centrate clarification at various process scales.
- tThe single-mode electrostatic separation mechanism and high-throughput media enable product recoveries of >95%.
- Provides comparable effluent quality to 3M™ Harvest RC Chromatographic Clarifier for a modern clarification platform.
- tLower consumption of buffer or water compared to depth filtration.
- tAlkaline-resistant capsules for pre-use sanitization.
Suggested Applications
- BC4, BC25, BC170, BC340, BC1020, BC2300 and BC18400: Biopharmaceutical processing applications of aqueous-based pharmaceuticals (drugs) and vaccines in accordance with the product instructions and specifications, cGMP and GLP requirements, where applicable.
Product specifications
| Industries |
Industries
Biopharmaceutical manufacturing |
| Net Weight (Metric) |
Net Weight (Metric)
75.8 gram, 3.4 kilogram, 9.8 kilogram, 1.1 kilogram, 1.6 kilogram, 69.2 gram, 14.3 gram |
| Filter Technology |
Filter Technology
Anion exchange chromatography |
| Micron Rating |
Micron Rating
0.2 micrometer |
| Product Series |
Product Series
Harvest RC |
| Flow Rate (Metric) |
Flow Rate (Metric)
4.2 milliliter per minute, 380 milliliter per minute, 2.7 liter per minute, 57 milliliter per minute, 170 milliliter per minute, 0.53 milliliter per minute |
| Flow Rate (Imperial) |
Flow Rate (Imperial)
0.001 gallon per minute, 0.084 gallon per minute, 0.594 gallon per minute, 0.013 gallon per minute, 0.037 gallon per minute, 0 gallon per minute |
| Overall Height (Imperial) |
Overall Height (Imperial)
6.34 inch, 3.39 inch, 2.24 inch, 7.99 inch, 4.09 inch, 5.98 inch, 2.09 inch, 2.4 inch, 3.5 inch, 2.32 inch |
| Overall Diameter (Imperial) |
Overall Diameter (Imperial)
4.37 inch, 3.03 inch, 17.8 inch, 9.49 inch, 1.14 inch, 1.69 inch |
| Overall Length (Imperial) |
Overall Length (Imperial)
5 inch |
| Overall Width (Metric) |
Overall Width (Metric)
8.6 centimeter |
| Overall Length (Metric) |
Overall Length (Metric)
12.7 centimeter |
| Overall Diameter (Metric) |
Overall Diameter (Metric)
111 millimeter, 7.7 centimeter, 45.2 centimeter, 24.1 centimeter, 2.9 centimeter, 4.3 centimeter |
| End Modification |
End Modification
3/4" Sanitary, 1-1/2" Sanitary, Luer-Lok, Non Pertinent |
| Filter Type |
Filter Type
Single Use |
| Overall Width (Imperial) |
Overall Width (Imperial)
3.39 inch |
| Application |
Application
Harvest and clarification |
| Overall Height (Metric) |
Overall Height (Metric)
161 millimeter, 8.6 centimeter, 5.7 centimeter, 20.3 centimeter, 10.4 centimeter, 15.2 centimeter, 5.3 centimeter, 6.1 centimeter, 8.9 centimeter, 5.9 centimeter |
