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3M™ Emphaze™ AEX Hybrid Purifier

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3M™ Emphaze™ AEX Hybrid Purifier Family

About the product

The Emphaze™ AEX Hybrid Purifier is an all-synthetic, multi-mechanism clarifying product that contains a Q-functional anion exchange media and a fine particle, bioburden reduction membrane. This product can substantially reduce turbidity, DNA, HCP and bioburden for improved downstream purification.

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Product name and IDs 3M ID Overall Diameter (Imperial) Overall Diameter (Metric) End Modification Micron Rating Flow Rate (Imperial) Overall Height (Imperial) Overall Height (Metric) Flow Rate (Metric) Filter Type Net Weight (Metric) Application Filter Technology Industries Product Series Brand

3M ID

7100179206

Overall Diameter (Imperial)

1.6900 INCH

Overall Diameter (Metric)

4.3000 CENTIMETER

End Modification

Luer Loc

Micron Rating

0.2000 MICROMETER

Flow Rate (Imperial)

0.0000 GALLON_PER_MINUTE

Overall Height (Imperial)

1.8900 INCH

Overall Height (Metric)

4.8000 CENTIMETER

Flow Rate (Metric)

0.4000 MILLILITER_PER_MINUTE

Filter Type

Single Use

Net Weight (Metric)

9.0000 GRAM

Application

Harvest and clarification

Filter Technology

Anion exchange chromatography

Industries

Biopharmaceutical manufacturing

Product Series

AEX

Brand

Emphaze™

3M ID

7100174193

Overall Diameter (Imperial)

1.6900 INCH

Overall Diameter (Metric)

4.3000 CENTIMETER

End Modification

Luer Loc

Micron Rating

0.2000 MICROMETER

Flow Rate (Imperial)

0.0000 GALLON_PER_MINUTE

Overall Height (Imperial)

2.3200 INCH

Overall Height (Metric)

5.9000 CENTIMETER

Flow Rate (Metric)

1.4000 MILLILITER_PER_MINUTE

Filter Type

Single Use

Net Weight (Metric)

14.5000 GRAM

Application

Harvest and clarification

Filter Technology

Anion exchange chromatography

Industries

Biopharmaceutical manufacturing

Product Series

AEX

Brand

Emphaze™

3M ID

7100166976

Overall Diameter (Imperial)

8.5000 INCH

Overall Diameter (Metric)

21.6000 CENTIMETER

End Modification

3/4 in Sanitary Connectors

Micron Rating

0.2000 MICROMETER

Flow Rate (Imperial)

0.0220 GALLON_PER_MINUTE

Overall Height (Imperial)

4.0600 INCH

Overall Height (Metric)

10.3000 CENTIMETER

Flow Rate (Metric)

100.0000 MILLILITER_PER_MINUTE

Filter Type

Single Use

Net Weight (Metric)

1.1000 KILOGRAM

Application

Harvest and clarification

Filter Technology

Anion exchange chromatography

Industries

Biopharmaceutical manufacturing

Product Series

AEX

Brand

Emphaze™

3M ID

7100158437

Overall Diameter (Imperial)

17.8000 INCH

Overall Diameter (Metric)

45.2000 CENTIMETER

End Modification

1 1/2 in Sanitary Connectors

Micron Rating

0.2000 MICROMETER

Flow Rate (Imperial)

1.0340 GALLON_PER_MINUTE

Overall Height (Imperial)

7.9900 INCH

Overall Height (Metric)

20.3000 CENTIMETER

Flow Rate (Metric)

4700.0000 MILLILITER_PER_MINUTE

Filter Type

Single Use

Net Weight (Metric)

9.5000 KILOGRAM

Application

Harvest and clarification

Filter Technology

Anion exchange chromatography

Industries

Biopharmaceutical manufacturing

Product Series

AEX

Brand

Emphaze™

3M ID

7100158436

Overall Diameter (Imperial)

17.8000 INCH

Overall Diameter (Metric)

45.2000 CENTIMETER

End Modification

1 1/2 in Sanitary Connectors

Micron Rating

0.2000 MICROMETER

Flow Rate (Imperial)

0.1500 GALLON_PER_MINUTE

Overall Height (Imperial)

2.2400 INCH

Overall Height (Metric)

5.7000 CENTIMETER

Flow Rate (Metric)

680.0000 MILLILITER_PER_MINUTE

Filter Type

Single Use

Net Weight (Metric)

3.4000 KILOGRAM

Application

Harvest and clarification

Filter Technology

Anion exchange chromatography

Industries

Biopharmaceutical manufacturing

Product Series

AEX

Brand

Emphaze™

3M ID

7100158435

Overall Diameter (Imperial)

8.5000 INCH

Overall Diameter (Metric)

21.6000 CENTIMETER

End Modification

3/4 in Sanitary Connectors

Micron Rating

0.2000 MICROMETER

Flow Rate (Imperial)

0.0660 GALLON_PER_MINUTE

Overall Height (Imperial)

5.9800 INCH

Overall Height (Metric)

15.2000 CENTIMETER

Flow Rate (Metric)

300.0000 MILLILITER_PER_MINUTE

Filter Type

Single Use

Net Weight (Metric)

1.6000 KILOGRAM

Application

Harvest and clarification

Filter Technology

Anion exchange chromatography

Industries

Biopharmaceutical manufacturing

Product Series

AEX

Brand

Emphaze™

3M ID

7100158434

Overall Diameter (Imperial)

3.0300 INCH

Overall Diameter (Metric)

7.7000 CENTIMETER

End Modification

3/4 in Sanitary Connectors

Micron Rating

0.2000 MICROMETER

Flow Rate (Imperial)

0.0020 GALLON_PER_MINUTE

Overall Height (Imperial)

3.4600 INCH

Overall Height (Metric)

8.8000 CENTIMETER

Flow Rate (Metric)

8.0000 MILLILITER_PER_MINUTE

Filter Type

Single Use

Net Weight (Metric)

77.0000 GRAM

Application

Harvest and clarification

Filter Technology

Anion exchange chromatography

Industries

Biopharmaceutical manufacturing

Product Series

AEX

Brand

Emphaze™

3M ID

7100158433

Overall Diameter (Imperial)

3.0300 INCH

Overall Diameter (Metric)

7.7000 CENTIMETER

End Modification

Luer Loc

Micron Rating

0.2000 MICROMETER

Flow Rate (Imperial)

0.0020 GALLON_PER_MINUTE

Overall Height (Imperial)

1.7700 INCH

Overall Height (Metric)

4.5000 CENTIMETER

Flow Rate (Metric)

8.0000 MILLILITER_PER_MINUTE

Filter Type

Single Use

Net Weight (Metric)

71.0000 GRAM

Application

Harvest and clarification

Filter Technology

Anion exchange chromatography

Industries

Biopharmaceutical manufacturing

Product Series

AEX

Brand

Emphaze™

3M ID

7100158416

Overall Diameter (Imperial)

8.5000 INCH

Overall Diameter (Metric)

21.6000 CENTIMETER

End Modification

3/4 in Sanitary Connectors

Micron Rating

0.2000 MICROMETER

Flow Rate (Imperial)

0.0110 GALLON_PER_MINUTE

Overall Height (Imperial)

4.0600 INCH

Overall Height (Metric)

10.3000 CENTIMETER

Flow Rate (Metric)

50.0000 MILLILITER_PER_MINUTE

Filter Type

Single Use

Net Weight (Metric)

1.0000 KILOGRAM

Application

Harvest and clarification

Filter Technology

Anion exchange chromatography

Industries

Biopharmaceutical manufacturing

Product Series

AEX

Brand

Emphaze™

3M ID

7100048384

Overall Diameter (Imperial)

17.8000 INCH

Overall Diameter (Metric)

45.2120 CENTIMETER

End Modification

1 1/2 in Sanitary Connectors

Micron Rating

0.2000 MICROMETER

Flow Rate (Imperial)

1.0780 GALLON_PER_MINUTE

Overall Height (Imperial)

7.9900 INCH

Overall Height (Metric)

20.3000 CENTIMETER

Flow Rate (Metric)

4900.0000 MILLILITER_PER_MINUTE

Filter Type

Single Use

Net Weight (Metric)

9.2000 KILOGRAM

Application

Harvest and clarification

Filter Technology

Anion exchange chromatography

Industries

Biopharmaceutical manufacturing

Product Series

AEX

Brand

Emphaze™

3M ID

7100048383

Overall Diameter (Imperial)

17.8000 INCH

Overall Diameter (Metric)

45.2120 CENTIMETER

End Modification

1 1/2 in Sanitary Connectors

Micron Rating

0.2000 MICROMETER

Flow Rate (Imperial)

0.1540 GALLON_PER_MINUTE

Overall Height (Imperial)

2.2400 INCH

Overall Height (Metric)

5.7000 CENTIMETER

Flow Rate (Metric)

700.0000 MILLILITER_PER_MINUTE

Filter Type

Single Use

Net Weight (Metric)

3.1000 KILOGRAM

Application

Harvest and clarification

Filter Technology

Anion exchange chromatography

Industries

Biopharmaceutical manufacturing

Product Series

AEX

Brand

Emphaze™

Product Details

Excellent Filtration

Robustness performance defines our Emphaze™ AEX Hybrid Purifier. Users may see substantial reductions of DNA by more than 99.99%, as well a reduction in host cell proteins (HCP) of 25-35%. This clarifying product may also reduce bioburden by more than 99.9999% of Brevundimonas diminuta and turbidity reduction to often less than 5 NTU. The mAb recovery is often equal to or greater than 95%. These attributes may contribute to enhancing the contaminant clearance performance of protein A columns.

This type of purification is crucial because high levels of DNA may lead to protein precipitation or aggregation – either before or after the protein A column. Similarly, relatively high levels of HCP are seen in perfusion harvest and a large amount of HCP co-elutes with the protein from the Protein A column. The challenge for the downstream purification process is to consistently reduce DNA, HCP and other levels in the final product. Emphaze™ AEX Hybrid Purifier helps meet this challenge by providing consistent reduction of HCP, DNA and other undesirable elements.

How it Works

Emphaze™ AEX Hybrid Purifier is an all-synthetic, multi-mechanism clarifying single-use capsule containing a synthetic Q-functional anion exchange media integrated with a fine particle, bioburden reduction membrane. The anion exchange media is comprised of a quaternary amine hydrogel supported by a fine fiber nonwoven scaffold. Multiple 3M technology platforms were leveraged to produce a hyper-functionalized high purity polypropylene nonwoven containing covalently attached, thermally stable, water soluble polymer. The functional polymer accounts for roughly two-thirds of the mass of the anion exchange media.

The bioburden reduction membrane is a highly asymmetric, high loading capacity polyamide membrane which has distinct zones of decreasing pore size spanning a roughly 20X range and terminating with a 0.2 µm bioburden reduction rated pore size. All components of the Emphaze™ AEX Hybrid Purifier are compliant with United States Pharmacopeia (USP) <88> Class VI 70°C Biological Reactivity Tests, in vivo.

Using Science to Improve Filtration

The 3M™ Emphaze™ product represents a class of purification products that can be utilized to help redefine the manufacturing processes for the production of therapeutic proteins and other biologics. At 3M Purification Inc. we are committed to apply science to filtration and providing you with quality products.

Our technology, products and innovation reflect what we do for our customers every day: advance, enhance and improve their products and processes to enable their success. 3M Purification's dedicated technical services and laboratory personnel help solve customers’ most arduous separations problems. Our engineers work to provide solutions that reduce the overall cost of ownership and our researchers are constantly working on breakthroughs that make new separations platforms possible. Every day our products are used by researchers, process developers and manufacturing personnel for critical filtration, separation and process monitoring steps in the biopharmaceutical industry.

  • All-synthetic, highly functionalized media (contains no naturally-derived materials)
  • Asymmetric membrane terminating with 0.2 µm bioburden reduction zone
  • Excellent mAb recovery often equal to or greater than 95%
  • Substantial turbidity, DNA, HCP and bioburden reduction
  • Reduced surface area requirement of the downstream sterilizing grade membrane
  • May offer differentiated protection of the protein A column for enhanced contaminant clearance performance
  • All product components comply with United States Pharmacopeia (USP) <88> Class VI 70°C Biological Reactivity Tests, in vivo
  • Autoclavable

Product Specifications

Industries
Industries

Biopharmaceutical manufacturing

Net Weight (Metric)
Net Weight (Metric)

1.0000, 1.1000, 1.6000, 14.5000, 3.1000, 3.4000, 71.0000, 77.0000, 9.0000, 9.2000, 9.5000

Filter Technology
Filter Technology

Anion exchange chromatography

Micron Rating
Micron Rating

0.2000

Product Series
Product Series

AEX

Flow Rate (Metric)
Flow Rate (Metric)

8.0000, 0.4000, 1.4000, 100.0000, 300.0000, 4700.0000, 4900.0000, 50.0000, 680.0000, 700.0000

Flow Rate (Imperial)
Flow Rate (Imperial)

0.0000, 0.0020, 0.0110, 0.0220, 0.0660, 0.1500, 0.1540, 1.0340, 1.0780

Effective Filtration Area
Effective Filtration Area

0.0270 SQUARE_FOOT, 17.2700 SQUARE_FOOT, 2.4830 SQUARE_FOOT, 0.0010 SQUARE_FOOT, 0.0040 SQUARE_FOOT, 0.1830 SQUARE_FOOT, 0.3670 SQUARE_FOOT, 1.1010 SQUARE_FOOT

Brand
Brand

Emphaze™

Overall Height (Imperial)
Overall Height (Imperial)

2.2400, 4.0600, 7.9900, 1.7700, 1.8900, 2.3200, 3.4600, 5.9800

Overall Diameter (Imperial)
Overall Diameter (Imperial)

17.8000, 8.5000, 1.6900, 3.0300

Effective Filtration Area (Metric)
Effective Filtration Area (Metric)

0.2300 SQUARE_CENTIMETER, SQUARE_METER, 1.6000 SQUARE_CENTIMETER, SQUARE_METER, 25.0000 SQUARE_CENTIMETER, SQUARE_METER, 1.0000 SQUARE_CENTIMETER, SQUARE_METER, 1020.0000 SQUARE_CENTIMETER, SQUARE_METER, 170.0000 SQUARE_CENTIMETER, SQUARE_METER, 340.0000 SQUARE_CENTIMETER, SQUARE_METER, 4.0000 SQUARE_CENTIMETER, SQUARE_METER

Overall Diameter (Metric)
Overall Diameter (Metric)

21.6000, 4.3000, 45.2000, 45.2120, 7.7000

End Modification
End Modification

1 1/2 in Sanitary Connectors, 3/4 in Sanitary Connectors, Luer Loc

Filter Type
Filter Type

Single Use

Application
Application

HarvestAndClarification

Overall Height (Metric)
Overall Height (Metric)

10.3000, 20.3000, 5.7000, 15.2000, 4.5000, 4.8000, 5.9000, 8.8000

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