3M™ Zeta Plus™ VR Series Filtration Media
About the product
3M™ Zeta Plus™ VR Series Media reduces certain viruses from biological fluids and provides protection of downstream virus removal filters. Media Discs provide viral reduction at high flow rates in scalable cartridge configurations. Backed by our quality control testing, these products are designed for applications in biological and pharmaceutical filtration.
Product details
The removal and/or inactivation of contaminating viruses from biotherapeutics is a regulatory requirement for helping to ensure final product safety. 3M™ Zeta Plus™ depth filtration offers an economical approach to enhance the performance of other technologies for reduction of certain types of viruses. A range of scalable cartridge sizes and sanitary housings enables predictable performance at every stage of drug development from early stage discovery to commercial production.
Our 3M™ Zeta Plus™ VR Series filter media comprises a mixture of high surface area inorganic particles, cellulose, and a positively charged crosslinking polymer. This positive charge enhanced depth filtration combines mechanical entrapment and anion exchange for improved removal of many negatively charged containments. Depth filtration with anion exchange capacity may help protect chromatography columns or function as a prefilter to a size exclusion virus removal membrane filter.
Pharmaceutical Grade Product
The 3M™ Zeta Plus™ VR Series Filter Cartridges and laboratory capsules and discs are designed for use in biological applications where virus reduction is desired or where protection of downstream virus removal filters is required. The effluent characteristics of the 3M™ Zeta Plus™ VR Series Filter media has been tested following a number of protocols contained in the United States Pharmacopeia (USP) compendia. All components of construction including the filtration media have been tested to demonstrate compliance to USP <88> Class VI Biological Reactivity, in-vivo. These results are documented in an available Regulatory Support File.The manufacturing process, quality controls and regulatory oriented compliance reports are documented in a Drug Master File on record with the FDA. Every manufacturing lot of 3M™ Zeta Plus™ VR Series media is quality release tested for ion exchange capacity using a charged dye.
- With specific biological fluids, combined anion exchange and physical entrapment removal mechanisms provide an added level of viral reduction
- Quality release testing includes a media ion exchange capacity assay
- BC25 Laboratory capsules, as well as media discs and stainless housings, are ideal for selecting the best media grade using low challenge fluid volume
- A range of scalable cartridge sizes and sanitary housings enables predictable performance at every stage of drug development
Product specifications
| Industries |
Industries
Biopharmaceutical manufacturing |
| Brand |
Brand
Zeta Plus™ |
| Product Form |
Product Form
Disc |
| Overall Diameter (Imperial) |
Overall Diameter (Imperial)
1.85 inch, 3.54 inch |
| Filter Technology |
Filter Technology
Adsorbent |
| Overall Diameter (Metric) |
Overall Diameter (Metric)
47 millimeter, 90 millimeter |
| Filter Type |
Filter Type
Depth |
| Product Series |
Product Series
VR |
| Grade |
Grade
VR02, VR06 |
| Application |
Application
Harvest and clarification |