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3M™ Zeta Plus™ BC Series Filter Capsule with LA Series Media

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3M™ Zeta Plus™ BC Series Filter Capsule with LA Series Media

About the product

We offer the 3M™ Zeta Plus™ BC Series Filter Capsule with LA Series Media as single-use capsules designed for pharmaceutical manufacturing applications requiring the most stringent levels of organic and inorganic extractables and system cross-contamination controls.

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Product name and IDs 3M ID Overall Width (Imperial) Overall Width (Metric) Overall Diameter (Imperial) Overall Diameter (Metric) End Modification Filter Type Grade Application Filter Technology Industries Product Series Brand

3M ID

7100127428

Overall Width (Imperial)

9.84 inch

Overall Width (Metric)

25 centimeter

Overall Diameter (Imperial)

2.63 inch

Overall Diameter (Metric)

66.8 millimeter

End Modification

Luer

Filter Type

Depth

Grade

90LA

Application

Harvest and clarification

Filter Technology

Adsorbent

Industries

Biopharmaceutical manufacturing

Product Series

BC

Brand

Zeta Plus™

3M ID

7100123387

Overall Width (Imperial)

9.84 inch

Overall Width (Metric)

25 centimeter

Overall Diameter (Imperial)

2.63 inch

Overall Diameter (Metric)

66.8 millimeter

End Modification

Sanitary Fitting

Filter Type

Depth

Grade

60LA

Application

Harvest and clarification

Filter Technology

Adsorbent

Industries

Biopharmaceutical manufacturing

Product Series

BC

Brand

Zeta Plus™

3M ID

7010382092

Overall Width (Imperial)

9.84 inch

Overall Width (Metric)

25 centimeter

Overall Diameter (Imperial)

2.63 inch

Overall Diameter (Metric)

66.8 millimeter

End Modification

Sanitary Fitting

Filter Type

Depth

Grade

50LA

Application

Harvest and clarification

Filter Technology

Adsorbent

Industries

Biopharmaceutical manufacturing

Product Series

BC

Brand

Zeta Plus™

3M ID

7010381971

Overall Width (Imperial)

-

Overall Width (Metric)

-

Overall Diameter (Imperial)

2.63 inch

Overall Diameter (Metric)

66.8 millimeter

End Modification

Luer

Filter Type

Depth

Grade

60LA

Application

Harvest and clarification

Filter Technology

Adsorbent

Industries

Biopharmaceutical manufacturing

Product Series

LA

Brand

Zeta Plus™

3M ID

7010338565

Overall Width (Imperial)

9.84 inch

Overall Width (Metric)

25 centimeter

Overall Diameter (Imperial)

2.63 inch

Overall Diameter (Metric)

66.8 millimeter

End Modification

Luer

Filter Type

Depth

Grade

50LA

Application

Harvest and clarification

Filter Technology

Adsorbent

Industries

Biopharmaceutical manufacturing

Product Series

BC

Brand

Zeta Plus™

3M ID

7010315140

Overall Width (Imperial)

9.84 inch

Overall Width (Metric)

25 centimeter

Overall Diameter (Imperial)

2.63 inch

Overall Diameter (Metric)

66.8 millimeter

End Modification

Sanitary Fitting

Filter Type

Depth

Grade

90LA

Application

Harvest and clarification

Filter Technology

Adsorbent

Industries

Biopharmaceutical manufacturing

Product Series

BC

Brand

Zeta Plus™

3M ID

7010296373

Overall Width (Imperial)

-

Overall Width (Metric)

-

Overall Diameter (Imperial)

2.63 inch

Overall Diameter (Metric)

66.8 millimeter

End Modification

Sanitary Fitting

Filter Type

Depth

Grade

30LA

Application

Harvest and clarification

Filter Technology

Adsorbent

Industries

Biopharmaceutical manufacturing

Product Series

BC

Brand

Zeta Plus™

3M ID

7010296371

Overall Width (Imperial)

-

Overall Width (Metric)

-

Overall Diameter (Imperial)

2.63 inch

Overall Diameter (Metric)

66.8 millimeter

End Modification

Luer

Filter Type

Depth

Grade

30LA

Application

Harvest and clarification

Filter Technology

Adsorbent

Industries

Biopharmaceutical manufacturing

Product Series

LA

Brand

Zeta Plus™

Product details

The Zeta Plus BC Series Filter Capsule with LA Series Media comprises a mixture of high surface area inorganic particles, cellulose, and a positively charged crosslinking polymer. These filters have a reduced potential of yielding false positives in drug product endotoxin testing resulting from 1,3 beta-glucan interference in LAL (Endotoxin) assays. They are designed for the lowest organic and inorganic extractable levels of the 3M depth filter portfolio by aggressively extracting both the inorganic particles and cellulose fibers. The combination of filtration efficiency and throughput results from the balance between porosity and depth, and the relatively low level anion exchange capacity: removing some negatively charged soluble and sub‐micron particles via anion exchange, and larger particles by mechanical sieving.

The BC25 laboratory capsule is ideal for optimizing the filtration performance for each drug process by effectively screening the breadth of available single and dual layer media options. A scalable range of single-use capsules enables predictable performance at every stage of drug development from early stage discovery to commercial production.

Pharmaceutical Grade Product

The Zeta Plus LA Series Filter products are specifically designed for use in the manufacture of biopharmaceutical, vaccine, blood fractionation and small molecule API drug substances. The effluent characteristics of the Zeta Plus LA Series Filter media and capsules has been tested following a number of protocols contained in the United States Pharmacopeia (USP) compendia.

The Zeta Plus LA Series filter media is specifically designed to have the lowest organic and inorganic extractable levels of the entire 3M depth filter portfolio. Stringent product extractable specifications are controlled, in part, by aggressively extracting both the cellulose fibers and filter aids prior to producing the filtration media. Due to the pre-extraction of the cellulose fibers, the Zeta Plus LA Series filtration media has a reduced potential of yielding false positives in product endotoxin testing resulting from 1,3 beta-glucan interference in LAL assays.

Filtration Performance

Zeta Plus LA Series filter media comprises a mixture of high surface area inorganic particles, high surface area cellulose and a crosslinking polymer resin. The polymer resin has a positive charge as a result of a balance of secondary, tertiary and quaternary amines resulting in a relatively low anion exchange capacity. As such, Zeta Plus LA Series filters are a good choice in applications where the pharmaceutical product is negatively charged and product recovery may be of concern. By controlling the choice of raw materials and the formulation, a variety of filtration grades are produced that each have a balance of fine particle removal and throughput capacity.

Single-use Capsules

Ease of use, operating costs and development time may all be improved by using 3M's single-use capsules. Specifically, single‐use capsules may reduce batch-to-batch change over time, minimize the time required to develop and manage complex validated equipment cleaning protocols and reduce the large cleaning fluid volume demands of a production operation.

  • Designed to have the lowest organic and inorganic extractable levels in the 3M depth filter portfolio
  • Stringent product extractable specifications enabled by both pre-extracting of both cellulose fiber and filter aid
  • Reduced potential of 1,3 beta-glucan interference in product endotoxin testing based on the use of aggressively extracted cellulose fibers
  • Filtration performance optimized to a broad range of fluid challenges
  • Full range of scalable single-use capsules enables predictable performance at every stage of drug development from early stage discovery to commercial production

Product specifications

Industries
Industries

Biopharmaceutical manufacturing

Brand
Brand

Zeta Plus™

Overall Diameter (Imperial)
Overall Diameter (Imperial)

2.63 inch

Overall Width (Metric)
Overall Width (Metric)

25 centimeter

Filter Technology
Filter Technology

Adsorbent

Overall Diameter (Metric)
Overall Diameter (Metric)

66.8 millimeter

End Modification
End Modification

Sanitary Fitting, Luer

Filter Type
Filter Type

Depth

Grade
Grade

60LA, 50LA, 90LA, 30LA

Product Series
Product Series

BC, LA

Overall Width (Imperial)
Overall Width (Imperial)

9.84 inch

Application
Application

Harvest and clarification

BP PDP

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