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  1. 3M™ Harvest RC Chromatographic Clarifier

3M™ Harvest RC, BT500, 6/Case

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3M™ Harvest RC, BT500, 6/Case
3M™ Harvest RC Family with 3M™ Harvest RC Chromatographic Clarifier BT500
3M™ Harvest RC family with 3M™ Harvest RC Chromatographic Clarifier BT500
(1) Harvest RC Chromatographic Clarifier: Predictable scaling from discovery to manufacturing

1-4 of 13

About the product

The 3M™ Harvest RC Chromatographic Clarifier is a single stage single-use chromatographic clarification solution designed as an efficient option for harvesting and clarification of modern cell cultures. Clarification with this chromatographic clarifier offers fewer processing steps, higher yield and lower production time and costs.

Details

View other product options
  • OverallHeightImperial : 6.34 in
  • Industries : Biopharmaceutical manufacturing
  • OverallHeightMetric : 161 mm
  • Overall Diameter (Imperial) : 4.37 in
  • Overall Diameter (Metric) : 111 mm
  • Product Series : Harvest RC
  • Category name : Chromatography Filters
  • Application : Harvest and clarification

Product details

3M™ Harvest RC Chromatographic Clarifier

Single-stage chromatographic clarification for recombinant protein therapeutic manufacturing.

3M™ Harvest RC Chromatographic Clarifier
3M™ Harvest RC Chromatographic Clarifier encapsulates innovative synthetic fibrous anion exchange (AEX) chromatography media and a 0.2 µm polyether sulfone (PES) membrane. This enables a single-stage clarification process of low to high-density cell culture (>40 million cells per mL) with high product recovery and high fidelity of soluble and insoluble contaminant separation. Cells are bound inside the media by electrostatic charge interaction with the AEX chromatographic fibers. This results in the efficient retention of large and small particulates without developing a surface cake layer. The media can also remove soluble impurities which results in cleaner effluent than centrifugation or depth filtration.
Experience 3M innovation from lab to production scale.
Discovery phase solutions

Discovery phase solutions

Start your discovery process with lab-scale solutions that enable you to do your job in less time with less complexity.

Production-scale solutions

Production-scale solutions

Advance from lab to production scale predictably with the 3M™ Harvest RC Chromatographic Clarifier portfolio of lab and manufacturing capsules

Scalability

Scalability

Read these peer reviewed publications evaluating 3M™ Harvest RC Chromatographic Clarifier.
Chromatographic capture of cells to achieve single stage clarification in recombinant protein purification

Chromatographic capture of cells to achieve single stage clarification in recombinant protein purification

See how the 3M™ Harvest RC Chromatographic Clarifier compares as a single stage single-use platform for harvest and clarification.

Single-stage chromatographic clarification reduces cost of protein production

Single-stage chromatographic clarification reduces cost of protein production

See how the 3M™ Harvest RC Chromatographic Clarifier intensifies and reduces cost of non-mAb protein production.

  • Simplification of high cell density cell culture fluid clarification unit operations.
  • Remove cells, cell debris and DNA (<500 ppb) from the harvested cell culture fluid.
  • Optimized for PCV high density CHO cell culture (5-8% PCV)
  • Replacement of primary, secondary and guard membrane clarification stages.
  • Typical product recovery of 95+% (capsules)
  • Synthetic chromatographic harvest media with chemically defined extractables.
  • Predictable scaling from discovery to manufacturing.
  • Lower total cost of manufacturing compared to centrifugation and depth filtration.
  • Lower consumption of buffer and water compared to depth filtration.
  • Capsules fit into laboratory to manufacturing scale workflows.

Suggested Applications

  • Biopharmaceutical processing applications of aqueous based pharmaceutical (drugs) and vaccines in accordance with the product instructions and specifications, and cGMP requirements (for BC340, BC1020, BC2300 and BC16000) or GLP requirements (for CT15, WP6, BC4, BC25 and BT500), where applicable.

Product specifications

OverallHeightImperial
OverallHeightImperial

6.34 in

Industries
Industries

Biopharmaceutical manufacturing

OverallHeightMetric
OverallHeightMetric

161 mm

Overall Diameter (Imperial)
Overall Diameter (Imperial)

4.37 in

Overall Diameter (Metric)
Overall Diameter (Metric)

111 mm

Product Series
Product Series

Harvest RC

Category name
Category name

Chromatography Filters

Application
Application

Harvest and clarification

Resources

1-2 of 2 Resources

BT500 Lab Scale Sell Sheet

BT500 Lab Scale Sell Sheet

3M Harvest RC Chromatographic Lab Scale sell sheet including BT500, Global, ADA Compliant pdf

View Document

3M Harvest RC Chromatographic Clarifier Product Information Sheet

3M Harvest RC Chromatographic Clarifier Product Information Sheet

3M™ Harvest RC Chromatographic Clarifier Product information sheet, EN, GBL, ADA Compliant PDF

View Document

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