3M™ Harvest RC, WP6, EMP006HRC2FA, 4/Case

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3M™ Harvest RC, WP6, EMP006HRC2FA, 4/Case

3M™ Harvest RC Family with 3M™ Harvest RC Chromatographic Clarifier BT500

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About the product

The 3M™ Harvest RC Chromatographic Clarifier is a single stage single-use chromatographic clarification solution designed as an efficient option for harvesting and clarification of modern cell cultures. Clarification with this chromatographic clarifier offers fewer processing steps, higher yield and lower production time and costs.

Details

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Industries : Biopharmaceutical manufacturing
OverallLengthImperial : 5 in
Micron Rating : 0.2 μm
Product Series : Harvest RC
EndModification : Non Pertinent
OverallHeightImperial : 3.5 in
OverallLengthMetric : 12.7 cm
Overall Width (Metric) : 8.6 cm
OverallHeightMetric : 8.9 cm
Category name : Chromatography Filters
Filter Type : Single Use
Overall Width (Imperial) : 3.39 in
FilterTechnology : Anion exchange chromatography
Application : Harvest and clarification

Product details

3M™ Harvest RC Chromatographic Clarifier encapsulates innovative synthetic fibrous anion exchange (AEX) chromatography media and a 0.2 µm polyether sulfone (PES) membrane. This enables a single-stage clarification process of low to high-density cell culture (>40 million cells per mL) with high product recovery and high fidelity of soluble and insoluble contaminant separation. Cells are bound inside the media by electrostatic charge interaction with the AEX chromatographic fibers. This results in the efficient retention of large and small particulates without developing a surface cake layer. The media can also remove soluble impurities which results in cleaner effluent than centrifugation or depth filtration.

Experience 3M innovation from lab to production scale.

Discovery phase solutions

Start your discovery process with lab-scale solutions that enable you to do your job in less time with less complexity.

Production-scale solutions

Advance from lab to production scale predictably with the 3M™ Harvest RC Chromatographic Clarifier portfolio of lab and manufacturing capsules

Scalability

Read these peer reviewed publications evaluating 3M™ Harvest RC Chromatographic Clarifier.

Chromatographic capture of cells to achieve single stage clarification in recombinant protein purification

See how the 3M™ Harvest RC Chromatographic Clarifier compares as a single stage single-use platform for harvest and clarification.

Single-stage chromatographic clarification reduces cost of protein production

See how the 3M™ Harvest RC Chromatographic Clarifier intensifies and reduces cost of non-mAb protein production.

Simplification of high cell density cell culture fluid clarification unit operations.
Remove cells, cell debris and DNA (<500 ppb) from the harvested cell culture fluid.
Optimized for PCV high density CHO cell culture (5-8% PCV)
Replacement of primary, secondary and guard membrane clarification stages.
Typical product recovery of 95+% (capsules)
Synthetic chromatographic harvest media with chemically defined extractables.
Predictable scaling from discovery to manufacturing.
Lower total cost of manufacturing compared to centrifugation and depth filtration.
Lower consumption of buffer and water compared to depth filtration.
Capsules fit into laboratory to manufacturing scale workflows.

Suggested Applications

Biopharmaceutical processing applications of aqueous based pharmaceutical (drugs) and vaccines in accordance with the product instructions and specifications, and cGMP requirements (for BC340, BC1020, BC2300 and BC16000) or GLP requirements (for CT15, WP6, BC4, BC25 and BT500), where applicable.

Product specifications

Industries	Industries Biopharmaceutical manufacturing
OverallLengthImperial	OverallLengthImperial 5 in
Micron Rating	Micron Rating 0.2 μm
Product Series	Product Series Harvest RC
EndModification	EndModification Non Pertinent
OverallHeightImperial	OverallHeightImperial 3.5 in
OverallLengthMetric	OverallLengthMetric 12.7 cm
Overall Width (Metric)	Overall Width (Metric) 8.6 cm
OverallHeightMetric	OverallHeightMetric 8.9 cm
Category name	Category name Chromatography Filters
Filter Type	Filter Type Single Use
Overall Width (Imperial)	Overall Width (Imperial) 3.39 in
FilterTechnology	FilterTechnology Anion exchange chromatography
Application	Application Harvest and clarification

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3M™ Harvest RC, WP6, EMP006HRC2FA, 4/Case

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