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Biopharmaceutical purification resources

Solventum’s Purification and Filtration Business is now a part of Thermo Fisher Scientific. Drinking Water Filtration remains with Solventum. For more information, please visit here.

Chromatographic capture of cells to achieve single stage clarification in recombinant protein purification

We explored the impact of a novel single use technology employing chromatographic principle-based clarification for a process-intensified cell line technology. In this study, a 16% economic benefit ($/g) was observed using a single-use chromatographic clarification compared to traditional single-use clarification technology by improving the overall product cost through decreased operational complexity, higher loading capacity, increased product recovery, and higher impurity clearance.

Read the paper
Image of two lab workers, one examining vile of liquid.

Seeking drug manufacturing platform - Can drug platforms keep up with complex new molecules?

As therapies have grown in complexity, some drug manufacturing platforms have lost viability. To address a variety of modalities while continuing to operate efficiently, it is necessary to reinvent how physics and chemistry are utilized within these separation technologies.
3M embraces the alignment of our culture with that of customers who pursue high-risk initiatives with a goal of accomplishing truly disruptive outcomes.

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Image of a lab worker testing liquid at a bench with a laptop for data entry.

Single-stage chromatographic clarification of Chinese Hamster Ovary cell harvest reduces cost of protein production

The use of the 3M™ Harvest RC Chromatographic Clarifier, a single-stage chromatographic clarification product, is identified as an alternative strategy to a three-stage filtration train. Using bioprocess cost modeling, the overall cost of the clarification process was reduced by 17%–30% through process compression, depending on bioreactor scale.

Read our recent co-publication with Ambrx
Btec photoshoot 3M™ Harvest RC Centrate lab workers connecting tubes - 02

3M™ Harvest RC Chromatographic Clarifier platform videos

3M™ Emphaze™ AEX Hybrid Purifier

Watch now:

3M™ Innovation 3M™ Emphaze™ AEX Hybrid Purifier ; 3M™ Emphaze™ AEX Hybrid Purifier

3M™ Polisher ST videos

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