Anion exchange chromatography
We solve the challenges of process intensification and loading capacity
Protein purification has significant downstream effects, particularly when moving from lab to production, and can be challenging to scale while intensifying the process and achieving high loading capacity. Solventum brings innovative solutions to AEX polishing unit operations that incorporate both a Q-functionalised fibrous non-woven and an innovative guanidinium-functionalised membrane, which combined provide robust viral clearance and host cell protein reduction. Operating across a wide range of conditions, 3M™ Polisher ST allows you to do more with less. It’s also available for easy trialling, so our experts can show you how to optimise your process to address your manufacturing challenges.
Simplified, intensified, time and cost-efficient purification
3M™ Polisher ST video
Discover the technology, performance and efficiencies that 3M™ Polisher ST can offer your bioprocessing operation.
AEX technology
Think beyond quaternary ammonium (“Q”) functional media in your downstream polishing operation. The 3M™ Polisher ST has that - and more. With two complementary AEX-functional media in a single device, it has greater capacity and delivers higher purity and yield to your downstream polishing operation.
Explore 3M™ Polisher ST frequently asked questions
Yes. Modern chromatographic membranes such as 3M™ Polisher ST have been proven to be robust and scalable from the bench to production scale. This enables a single-use chromatographic device to replace a large, multi-use column, thereby saving space and buffers.
Yes. Newer anion exchange functionalities, such as guanidinium and, to a lesser extent, primary amines, have been shown to be able to remove problematic HCPs under a wider range of conditions, compared to traditional Q chemistries.
The advantages of the 3M™ Polisher ST include a more compact design, increased loading capacities, reduced buffer usage, and the elimination of the need for packing, repacking, and validation.
Yes, 3M™ Polisher ST is also an effective virus removal step as part of an orthogonal viral clearance technology platform. Under process conditions of pH 5.5 to 7.5 and 5 to 20 mS/cm, 4 to 7 LRV can be achieved. Viral clearance performance is independent of the format, for example, the traditional AEX column vs. 3M™ Polisher ST. Performance is directly related to the functional ligand, feed and process conditions used.
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