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3M™ Promogran Prisma™ Collagen Matrix with ORC and Silver

與其他膠原蛋白敷料不同

3M™ Promogran Prisma™ 膠原蛋白基質搭配ORC和銀色，經過隨機對照試驗1-2獨特配方且經證明有效。

聯絡代表
臨床醫生將3M™ Promogran Prisma™ Matrix應用於病人的腳跟，TIF檔案。
康復的基礎 Promogram 矩陣系列 資源 探索更多 聯絡我們
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康復的基礎
Promogram 矩陣系列
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療癒的基礎

臨床醫生對骶骨壓瘡施用3M™ Promogran Prisma™ Matrix

創造適當的療癒條件對於難以癒合的傷口至關重要。處理發炎和生物負擔是一個重要的步驟。雖然膠原蛋白對抗基質金屬蛋白酶（MMPs）有效，但它對彈性蛋白酶，另一種豐富的蛋白酶的影響有限。In vitro 研究顯示，將氧化再生纖維素（ORC）與膠原蛋白結合使用，比單獨使用膠原蛋白在降低MMP和彈性蛋白酶活性方面具有更大的效果，這兩者都是非癒合傷口的高度預測指標3-4。

 

彈性蛋白酶在難以癒合的傷口中扮演著關鍵角色。它在受傷後不久就會出現，並且可以損害包括5-7：

  • 纖維蛋白：有助於細胞粘附和遷移 
  • 彈性蛋白：提供組織彈性 
  • 生長因子：PDGF和EGF 

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參考資料：

  1. Chowdhry S.A, et al. Use of oxidised regenerated cellulose/collagen dressings versus standard of care over multiple wound types:a systematic review and meta-analysis. Int Wound J. 2021.  
  2. Chen Y, Du P, Lv G. A meta-analysis examined the effect of oxidised regenerated cellulose/collagen dressing on the management of chronic skin wounds. Int Wound J. 2023;20(5):1544-1551. doi:10.1111/iwj.14009CHENET AL.1551 
  3. Cullen B, Watt P, Lundqvist C, et al. The role of oxidized regenerated cellulose/collagen in chronic wound repair and its potential mechanism of action. Int J Biochem Cell Biol. 2002; 34(12):1544–1556. 
  4. Serena T, Cullen T, Bayliff S, et al. Defining a new diagnostic assessment parameter for wound care: Elevated protease activity, an indicator of non-healing for targeted treatment. Wound Repair Regen. 2016;24(3):589-595. 
  5. Gibson D, Cullen B, Legerstee R, Harding KG, Schultz G. MMPs made easy. Wounds International. 2009;1(1)1-6. 
  6. Weitz JI, Landmann SL, Crowley KA, Birken S, Morgan FJ. Development of an assay for in vivo human neutrophil elastase activity. Increased elastase activity in patients with alpha 1-proteinase inhibitor deficiency. J Clin Invest. 1986; 78:155-162. doi:10.1172/JCI112545. Cited by: Ferreira AV, Perelshtein I, Perkas N, Gedanken A, Cunha J, Cavaco-Paulo A. Detection of human neutrophil elastase (HNE) on wound dressings as marker of inflammation. Appl Microbiol Biot1echnol. 2017; 101:1443-1454. 
  7. Hasmann A, Gewessler U, Hulla E, et al. Sensor materials for the detection of human neutrophil elastase and cathepsin G activity in wound fluid. Exp Dermatol. 2011; 20(6):508-513. doi: 10.1111/j.1600-0625.2011.01256.x. Cited by: Ferreira AV, Perelshtein I, Perkas N, Gedanken A, Cunha J, Cavaco-Paulo A. Detection of human neutrophil elastase (HNE) on wound dressings as marker of inflammation. Appl Microbiol Biotechnol. 2017; 101:1443-1454. 
  8. Cullen B, et al. Early adoption of collagen/ORC therapies improves clinical outcome. Paper presented at: Wounds UK Harrogate, 2011.  
  9. Gottrup F, Cullen B, Karlsmark T, Bischoff-Mikkelsen M, Nisbet L, Gibson M. Randomized controlled trial on collagen/oxidized regenerated cellulose/silver treatment. Wound Repair & Regeneration. 2013; 21:1-10.  
  10. Veves A, Sheehan P, Pham HT. A randomised controlled trial of Promogran (a collagen/ oxidized regenerated cellulose dressing) vs standard treatment in the management of diabetic foot ulcers. Arch Surg. 2002; 137(7):822-827.  
  11. Vin, F., Teot, L. and Meaume, S. (2002) The healing properties of Promogran in venous leg ulcers. J Wound Care, 11, 335-341. 
  12. Snyder, R. et al. A Retrospective Study of Sequential Therapy with Advanced Wound Care Products versus Saline Gauze Dressings: Comparing Healing and Cost. Ostomy Wound Management. 2010; 56(11A):9–15. 
  13. Bourdillon KA, Delury C, Cullen B. Biofilms and delayed healing – an in vitro evaluation of silver and iodine containing dressings and their effect on bacterial and human cells. International Wound Journal. 2017. ISSN 1742-4801.