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3M™ Emphaze™ AEX Series Hybrid Purifier

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3M™ Emphaze™ AEX Series Hybrid Purifier

About the product

3M™ Emphaze AEX Hybrid Purifier is our single-use sterilisable and sanitisable. The all-synthetic purification media that contains a Q-functional anion exchange media and a fine particle and bioburden reduction membrane.

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Product details

Remove impurities in biopharmaceutical process streams such as DNA, host cell proteins (HCP) and viruses with our all-synthetic, single use 3M™ Emphaze AEX Hybrid Purifier. The composite purification media is comprised of three primary components: anion exchange nonwoven, microporous membrane, and membrane support. The anion exchange media is composed of four layers of polypropylene nonwoven with a covalently attached quaternary ammonium functional polymer. The bioburden reduction membrane is a highly asymmetric polyamide membrane which has nine zones of decreasing pore size, spanning approximately a 20 X range, and terminating with a 0.2 μm rated qualifying layer. This is followed by a polypropylene nonwoven used as a support layer in the capsule. Capsules There are two primary capsule configurations for the Emphaze AEX Hybrid Purifier, Laboratory and Scale-up capsules: - The Laboratory capsule (BV8) has an 8ml bed volume - The Scale-up capsules are constructed from a lenticular media cell design having bed volumes of 120 mls and 360 mls (BV 120 and BV 360 respectively) - The Production capsules are scaled to meet your manufacturing requirements and utilise manifolds in a holder for ease of use A full support package is available for 3M Emphaze AEX Hybrid Purifiers. This package includes Installation and Operation Guides, a Certificate of Quality and a Regulatory Support File.
  • Reduces turbidity, HCP, DNA and bioburden.
  • Excellent throughput and mAb recovery.
  • Enhanced capture column performance and protection.
  • Substantial turbidity, DNA, HCP and bioburden reduction.
  • Reduced surface area requirement of the downstream sterilizing grade membrane.
  • May offer differentiated protection of the protein A column for enhanced contaminant clearance performance.
  • All product components comply with United States Pharmacopeia (USP) Class VI 70°C Biological Reactivity Tests, in vivo.

Suggested Applications

  • Use for the clarification of mammalian cell cultures and to optimise downstream processes for monoclonal antibodies (mAbs)

Product specifications

FlowRateMetric
FlowRateMetric

100 ml/min

Industries
Industries

Biopharmaceutical manufacturing

Net Weight (Metric)
Net Weight (Metric)

1.1 kg

Filter Technology
Filter Technology

Anion exchange chromatography

Micron Rating
Micron Rating

0.2 μm

OverallDiameterImperial
OverallDiameterImperial

8.5 in

Product Series
Product Series

AEX

Flow Rate (Metric)
Flow Rate (Metric)

8 ml/min

categoryName
categoryName

Chromatography Filters

Flow Rate (Imperial)
Flow Rate (Imperial)

0.022 gal/min, 0.002 gal/min

Brand
Brand

Emphaze™

Overall Height (Imperial)
Overall Height (Imperial)

4.06 in, 3.46 in

OverallHeightMetric
OverallHeightMetric

10.3 cm

Overall Diameter (Imperial)
Overall Diameter (Imperial)

3.03 in

NetWeightMetric
NetWeightMetric

77 g

Overall Diameter (Metric)
Overall Diameter (Metric)

21.6 cm, 7.7 cm

End Modification
End Modification

3/4 in Sanitary Connectors

Category name
Category name

Chromatography Filters

Filter Type
Filter Type

Single Use

Trademark2
Trademark2

Emphaze™

Application
Application

Harvest and clarification

Overall Height (Metric)
Overall Height (Metric)

8.8 cm

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