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3M™ Harvest RC Chromatographic Clarifier

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3M™ Harvest RC Chromatographic Clarifier
3M(TM) Harvest RC family
3M(TM) Harvest RC family
3M™ Harvest RC family

About the product

3M™ Harvest RC is the next generation in harvest and clarification technology for high cell density cultures.

Product options

1-5 of Products

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Product details

This solution is designed as an efficient option to increase monoclonal antibody (mAb) yields while simplifying the upstream process by replacing the centrifuge and/or depth filtration unit operations.
  • Simplification of high cell density cell culture fluid clarification unit operations.
  • Remove cells, cell debris and DNA (<500 ppb) from the harvested cell culture fluid.
  • Optimised for PCV high density CHO cell culture (5-8% PCV)
  • Replacement of primary, secondary and guard membrane clarification stages.
  • Typical product recovery of 95+% (capsules)
  • Synthetic chromatographic harvest media with chemically defined extractables.
  • Predictable scaling from discovery to manufacturing.
  • Lower total cost of manufacturing compared to centrifugation and depth filtration.
  • Lower consumption of buffer and water compared to depth filtration.
  • Capsules fit into laboratory to manufacturing scale workflows.

Suggested Applications

  • Clarification for CHO harvest cell culture fluid
  • Single-stage chromatographic clarification
  • Single-stage chromatographic clarification

Product specifications

Industries
Industries

Biopharmaceutical manufacturing

Net Weight (Metric)
Net Weight (Metric)

75.8 g, 9.8 kg, 1.1 kg, 1.6 kg, 69.2 g, 10 g

Filter Technology
Filter Technology

Anion exchange chromatography

Micron Rating
Micron Rating

0.2 μm

OverallDiameterImperial
OverallDiameterImperial

3.03 in

Product Series
Product Series

Harvest RC

categoryName
categoryName

Chromatography Filters

Flow Rate (Imperial)
Flow Rate (Imperial)

0.001 gal/min, 0.1 gal/min, 0.594 gal/min, 0 gal/min

OverallHeightImperial
OverallHeightImperial

8.74 in, 2.09 in

Overall Height (Imperial)
Overall Height (Imperial)

0.63 in, 3.39 in, 2.24 in, 4.09 in, 5.98 in, 2.4 in, 3.46 in, 2.32 in

OverallHeightMetric
OverallHeightMetric

22.2 cm, 5.9 cm

FlowRateImperial
FlowRateImperial

0.013 gal/min, 0.037 gal/min

NetWeightMetric
NetWeightMetric

250 g, 3.4 kg, 14.3 g

End Modification
End Modification

3/4 in Sanitary, 1 1/2 in Sanitary, Luer Lock

Category name
Category name

Chromatography Filters

ProductSeries
ProductSeries

Harvest RC

Overall Height (Metric)
Overall Height (Metric)

16.1 mm, 8.6 cm, 5.7 cm, 10.4 cm, 15.2 cm, 5.3 cm, 6.1 cm, 8.8 cm

FlowRateMetric
FlowRateMetric

0.53 ml/min

MicronRating
MicronRating

0.2 μm

OverallDiameterMetric
OverallDiameterMetric

45.2 cm, 24.1 cm, 7.7 cm, 4.3 cm

Flow Rate (Metric)
Flow Rate (Metric)

4.2 ml/min, 0.38 l/min, 2.68 l/min, 57 ml/min, 170 ml/min

EndModification
EndModification

1 1/2 in Sanitary, 3/4 in Sanitary

FilterType
FilterType

Single Use

Overall Diameter (Imperial)
Overall Diameter (Imperial)

43.7 in, 17.8 in, 9.49 in, 1.14 in, 1.69 in

Overall Length (Imperial)
Overall Length (Imperial)

5.04 in

Overall Width (Metric)
Overall Width (Metric)

8.5 cm

Overall Length (Metric)
Overall Length (Metric)

12.8 cm

Overall Diameter (Metric)
Overall Diameter (Metric)

111 cm, 7.7 cm, 45.2 cm, 24.1 cm, 2.9 cm

Filter Type
Filter Type

Single Use

FilterTechnology
FilterTechnology

Anion exchange chromatography

Overall Width (Imperial)
Overall Width (Imperial)

3.35 in

Application
Application

Harvest and clarification

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