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3M™ Polisher ST

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3M™ Polisher ST

Om produkten

The 3M™ Polisher ST is a fully encapsulated single-use anion exchange (AEX) product. It is intended to reduce host cell protein, viruses, and other negatively charged contaminants in a flow-through polishing chromatography mode in biopharmaceutical process streams. The 3M™ Polisher ST is a synthetic, hybrid purifier containing two complementary AEX-functional media: a quaternary ammonium (“Q”) functional nonwoven and a guanidinium-functional membrane.

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Produktdetaljer

The Q-functional nonwoven provides reduction of turbidity (when present) and DNA. It also provides a portion of the product’s AEX capacity for HCP and virus reduction. Guanidinium functionalised membrane downstream of the functionalised nonwoven provides additional AEX polishing capacity. The novel guanidinium functionality of the downstream AEX polishing membrane mimics the amino acid, arginine, one of the three positively charged naturally occurring standard amino acids that make up proteins and is responsible for viral clearance and high salt tolerance.
  • Unaffected by process fluid turbidity up to 40 NTU.
  • The 3M™ Polisher ST is a single use multi-mechanism membrane adsorber which contains a Q-functional anion exchange non woven media and guanidinium functionalised membrane. This product removes residual turbidity, DNA and HCP and provides robust virus clearance for improved downstream/polishing purification.
  • Single-use technology as a cost-efficient option to increase biomass production by delivering high purity and yield in the downstream polishing unit operation in therapeutic recombinant protein process in biologically relevant operating conditions.
  • Replaces downstream AEX polishing column for reduction of HCP and virus in a salt tolerant (ST) manner as a single-use solution.
  • Provides DNA reduction in a salt tolerant (ST) manner compared with conventional Q-functional AEX resins.

Produktspecifikationer

Användningsområden
Användningsområden

Anjonbyte

Industries
Industries

Läkemedelstillverkning

FlowRateMetric
FlowRateMetric

340 ml/min

MicronRating
MicronRating

0.8 μm

Filterteknik
Filterteknik

Anjonbyteskromatografi

Mikrometerklassning
Mikrometerklassning

0.8 μm

Slutmodifiering
Slutmodifiering

3/4 in Sanitary Connectors, Luer Loc, 1 1/2 in Sanitary Connectors

Total diameter (metrisk)
Total diameter (metrisk)

7.7 cm, 4.3 cm, 24.1 cm, 45.2 cm, 45 cm

Totalhöjd (imperial)
Totalhöjd (imperial)

3.39 in, 1.89 in, 3.98 in, 1.93 in, 2.32 in, 5.98 in, 3.03 in, 8.74 in

EndModification
EndModification

3/4 in Sanitary Connectors

categoryName
categoryName

Kromatografifilter

Totalhöjd (metrisk)
Totalhöjd (metrisk)

8.6 cm, 4.8 cm, 10.1 cm, 4.9 cm, 5.9 cm, 15.2 cm, 7.7 cm, 22.2 cm

Flödestakt (metrisk)
Flödestakt (metrisk)

25 ml/min, 1 ml/min, 4 ml/min, 1020 ml/min, 170 ml/min, 2.3 l/min

Kategorinamn
Kategorinamn

Kromatografifilter

Flödestakt (imperial)
Flödestakt (imperial)

0.005 gal/min, 0 gal/min, 0.075 gal/min, 0.001 gal/min, 0.224 gal/min, 0.037 gal/min, 0.506 gal/min

NetWeightMetric
NetWeightMetric

78 g

Branscher
Branscher

Läkemedelstillverkning

Övergripande Diameter (Imperial)
Övergripande Diameter (Imperial)

3.03 in, 1.69 in, 9.49 in, 17.8 in, 17.72 in

Filtertyp
Filtertyp

Engångsbruk

Produktserie
Produktserie

Polermaskin ST

Nettovikt
Nettovikt

10 g, 1.2 kg, 72 g, 15.5 g, 1.8 kg, 1.1 kg, 3.8 kg, 12.7 kg

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