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3M™ Polisher ST

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3M™ Polisher ST

Om produktet

The 3M™ Polisher ST is a fully encapsulated single-use anion exchange (AEX) product. It is intended to reduce host cell protein, viruses, and other negatively charged contaminants in a flow-through polishing chromatography mode in biopharmaceutical process streams. The 3M™ Polisher ST is a synthetic, hybrid purifier containing two complementary AEX-functional media: a quaternary ammonium (“Q”) functional nonwoven and a guanidinium-functional membrane.

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Produktdetaljer

The Q-functional nonwoven provides reduction of turbidity (when present) and DNA. It also provides a portion of the product’s AEX capacity for HCP and virus reduction. Guanidinium functionalised membrane downstream of the functionalised nonwoven provides additional AEX polishing capacity. The novel guanidinium functionality of the downstream AEX polishing membrane mimics the amino acid, arginine, one of the three positively charged naturally occurring standard amino acids that make up proteins and is responsible for viral clearance and high salt tolerance.
  • Unaffected by process fluid turbidity up to 40 NTU.
  • The 3M™ Polisher ST is a single use multi-mechanism membrane adsorber which contains a Q-functional anion exchange non woven media and guanidinium functionalised membrane. This product removes residual turbidity, DNA and HCP and provides robust virus clearance for improved downstream/polishing purification.
  • Single-use technology as a cost-efficient option to increase biomass production by delivering high purity and yield in the downstream polishing unit operation in therapeutic recombinant protein process in biologically relevant operating conditions.
  • Replaces downstream AEX polishing column for reduction of HCP and virus in a salt tolerant (ST) manner as a single-use solution.
  • Provides DNA reduction in a salt tolerant (ST) manner compared with conventional Q-functional AEX resins.

Produktspecifikasjoner

Industries
Industries

Biofarmasøytisk produksjon

Avslutt endring
Avslutt endring

3/4 in Sanitary Connectors, Luer Loc, 1 1/2 in Sanitary Connectors

OverallDiameterImperial
OverallDiameterImperial

3.03 in

categoryName
categoryName

Kromatografiske filtre

Nettovekt (metrisk)
Nettovekt (metrisk)

78 g, 10 g, 1.2 kg, 72 g, 15.5 g, 1.1 kg, 3.8 kg, 12.7 kg

OverallHeightImperial
OverallHeightImperial

3.98 in

OverallHeightMetric
OverallHeightMetric

4.8 cm, 10.1 cm, 4.9 cm

FlowRateImperial
FlowRateImperial

0.005 gal/min, 0.001 gal/min

Total høyde (Metrisk)
Total høyde (Metrisk)

8.6 cm, 5.9 cm, 15.2 cm, 10.1 cm, 7.7 cm, 22.2 cm

NetWeightMetric
NetWeightMetric

1.8 kg

ProductSeries
ProductSeries

Poleringsmaskin ST

Total diameter (Imperial)
Total diameter (Imperial)

3.03 in, 1.69 in, 9.49 in, 17.8 in, 17.72 in

Kategorinavn
Kategorinavn

Kromatografiske filtre

Filtertype
Filtertype

Engangsbruk

Produktserier
Produktserier

Poleringsmaskin ST

FlowRateMetric
FlowRateMetric

1 ml/min, 4 ml/min

MicronRating
MicronRating

0.8 μm

Mirkonrate
Mirkonrate

0.8 μm

OverallDiameterMetric
OverallDiameterMetric

24.1 cm

Flowfrekvens (Imperial)
Flowfrekvens (Imperial)

0 gal/min, 0.075 gal/min, 0.005 gal/min, 0.224 gal/min, 0.037 gal/min, 0.506 gal/min

Bruksområder
Bruksområder

Anionebytte

Filterteknologi
Filterteknologi

Anionbytterkromatografi

Flowfrekvens (Metrisk)
Flowfrekvens (Metrisk)

25 ml/min, 340 ml/min, 4 ml/min, 1020 ml/min, 170 ml/min, 2.3 l/min

Hel diameter (Metrisk)
Hel diameter (Metrisk)

7.7 cm, 4.3 cm, 24.1 cm, 45.2 cm, 45 cm

EndModification
EndModification

1 1/2 in Sanitary Connectors

Application
Application

Anionebytte

Total høyde (Imperial)
Total høyde (Imperial)

3.39 in, 1.89 in, 3.98 in, 1.93 in, 2.32 in, 5.98 in, 3.03 in, 8.74 in

Bransjer
Bransjer

Biofarmasøytisk produksjon