Polisher ST, BC1020, 1/Case

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About the product

The 3M™ Polisher ST is a fully encapsulated single-use anion exchange (AEX) product. It is intended to reduce host cell protein, viruses, and other negatively charged contaminants in a flow-through polishing chromatography mode in biopharmaceutical process streams. The 3M™ Polisher ST is a synthetic, hybrid purifier containing two complementary AEX-functional media: a quaternary ammonium (“Q”) functional nonwoven and a guanidinium-functional membrane.

Details

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FlowRateMetric : 1020 ml/min
Industries : Biopharmaceutical manufacturing
OverallDiameterMetric : 24.1 cm
Micron Rating : 0.8 μm
OverallDiameterImperial : 9.49 in
Product Series : Polisher ST
categoryName : Chromatography Filters
Global Catalog Number : BC1020
Overall Height (Imperial) : 5.98 in
OverallHeightMetric : 15.2 cm
FlowRateImperial : 0.224 gal/min
NetWeightMetric : 1.8 kg
End Modification : 3/4 in Sanitary Connectors
Filter Type : Single Use
FilterTechnology : Anion exchange chromatography
Application : Anion exchange

Product details

The Q-functional nonwoven provides reduction of turbidity (when present) and DNA. It also provides a portion of the product’s AEX capacity for HCP and virus reduction. Guanidinium functionalised membrane downstream of the functionalised nonwoven provides additional AEX polishing capacity. The novel guanidinium functionality of the downstream AEX polishing membrane mimics the amino acid, arginine, one of the three positively charged naturally occurring standard amino acids that make up proteins and is responsible for viral clearance and high salt tolerance.

Unaffected by process fluid turbidity up to 40 NTU.
The 3M™ Polisher ST is a single use multi-mechanism membrane adsorber which contains a Q-functional anion exchange non woven media and guanidinium functionalised membrane. This product removes residual turbidity, DNA and HCP and provides robust virus clearance for improved downstream/polishing purification.
Single-use technology as a cost-efficient option to increase biomass production by delivering high purity and yield in the downstream polishing unit operation in therapeutic recombinant protein process in biologically relevant operating conditions.
Replaces downstream AEX polishing column for reduction of HCP and virus in a salt tolerant (ST) manner as a single-use solution.
Provides DNA reduction in a salt tolerant (ST) manner compared with conventional Q-functional AEX resins.

Product specifications

FlowRateMetric	FlowRateMetric 1020 ml/min
Industries	Industries Biopharmaceutical manufacturing
OverallDiameterMetric	OverallDiameterMetric 24.1 cm
Micron Rating	Micron Rating 0.8 μm
OverallDiameterImperial	OverallDiameterImperial 9.49 in
Product Series	Product Series Polisher ST
categoryName	categoryName Chromatography Filters
Global Catalog Number	Global Catalog Number BC1020
Overall Height (Imperial)	Overall Height (Imperial) 5.98 in
OverallHeightMetric	OverallHeightMetric 15.2 cm
FlowRateImperial	FlowRateImperial 0.224 gal/min
NetWeightMetric	NetWeightMetric 1.8 kg
End Modification	End Modification 3/4 in Sanitary Connectors
Filter Type	Filter Type Single Use
FilterTechnology	FilterTechnology Anion exchange chromatography
Application	Application Anion exchange