Skip to main content

We've detected that you're visiting from United States of America. Would you like to switch languages for tailored content?

->

Biopharmaceutical purification

Solventum’s Purification and Filtration Business is now a part of Thermo Fisher Scientific. Drinking Water Filtration remains with Solventum. For more information, please visit hereopens in a new tab.

Pioneering high-quality bioprocessing filtration solutions

As you adjust to the growing demands for volume, customisation, speed to market and scalability in the biopharmaceutical industry, Solventum is here to help. We partner with you, utilising state-of-the-art, sustainable technologies in filtration, clarification and purification to simplify your bioprocessing filtration requirements.

Ask an expert
Two male engineers/scientists in white coats and blue gloves
Overview Solutions Applications Application specialists Sustainability School of Purification Next steps Ask an expert
On this page...
Overview
Solutions
Applications
Application specialists
Sustainability
School of Purification
Next steps
Ask an expert

An unwavering commitment to quality, efficiency, and sustainability

Navigating biopharmaceutical purification processes can be challenging. Whether for clinical trials or accelerating life-saving drugs to market, you want to deliver solutions in a sustainable manner, balance costs and comply with regulatory requirements — all at the same time. That’s why we’re dedicated to innovation across our portfolio of purification solutions built to address your complex bioprocess challenges. By intensifying unit operations and reducing unnecessary consumables and waste, our solutions can help you optimise your process efficiencies. And they’re designed to deliver high-quality and cost-effective biopharmaceutical output that safeguards molecule integrity and facilitates process scalability. 

0:00 / 1:15

Advanced technology solutions in bioprocessing purification

Harvest and clarification

Navigating the intricacies of biopharmaceutical harvest and clarification can be complex. We understand your challenges and the fundamental role that efficient harvest and clarification processes play in driving product yield and quality. This is why we've developed advanced, easy-to-use solutions that help you streamline these crucial stages. Our technology empowers you to efficiently remove cells and cell debris, and reduce soluble impurities to enhance consistency, increase yield and speed up your downstream process so you can focus on producing a high-quality drug substance.

Learn more about harvest and clarification solutions
Icon of harvest and clarification

Anion exchange chromatography

Protein purification has significant downstream effects, particularly when moving from lab to production, and can be challenging to scale while intensifying the process and achieving high load capacity. Solventum brings innovative solutions with AEX polishing chromatography that incorporates both a Q-functionalised non-woven fibre and an innovative guanidinium ligand membrane, which combined provide robust viral clearance and host cell protein reduction. Operating across a wide range of conditions, the 3M™ Polisher ST allows you to achieve more with less. We bring expertise in solutions that help you accelerate your speed to market, while intensifying your downstream processes.

Learn more about anion exchange chromatography solutions
Icon of anion exchange chromatography

Sterile filtration

Our membrane filtration solutions are designed to meet your unique needs, across industries and applications. Our range of membrane types, each with proven performance and compliance standards that you can count on, will allow you to realise the full potential of your designs and devices, empowering you to bring your next big idea to life. The 3M™ LifeASSURE™ PDA Series Filter provides high surface area and advanced pleat technology that reduces fine particles, microorganisms and, as a result, fouling. Our technologies are designed to deliver quality solutions to membrane filtration processes across industries.

Learn more about sterile filtration solutions
Icon of sterile filtration

Partnering to enhance your bioprocessing operations

Monoclonal antibody (mAb) and recombinant protein manufacturing

In monoclonal antibody (mAb) and recombinant protein manufacturing, achieving optimal product yield and quality while managing costs can be challenging. At Solventum, we understand these demands and offer a wide range of solutions to meet your unique needs for efficient and effective impurity removal in the mAb and recombinant protein manufacturing production process, a critical element across all of our bioprocessing solutions.

Our cutting-edge technologies are designed to enhance your production processes, ensuring efficient impurity removal and upgrading filtrate quality. The 3M™ Harvest RC Chromatographic Clarifier platform  is a high-capacity, synthetic, single-use clarification platform that includes both a direct clarification solution and a centrate clarification solution. The 3M™ Zeta Plus™ Depth Filters, 3M™ Emphaze™ AEX Hybrid Purifier and 3M™ Polisher ST dovetail into your current processes at specific stages.

Learn more about harvest and clarification Learn more about anion exchange chromatography Learn more about sterile filtration
BTEC photoshoot 3M™ Harvest RC Centrate lab workers setting up equipment - 119

Gene therapy

In the rapidly evolving field of gene therapy, the challenges of ensuring efficiency, safety and scalability are ever-present. As our understanding of cell biology advances, vector-directed gene therapy is gaining ground as a significant future drug modality. As demand grows for this life-transforming therapy, our innovative solutions may help you deliver high quality drug substances.

Our bioprocessing filtration and purification products can be integrated into your manufacturing processes for gene therapy drug products that utilise AAVs as viral vectors, similar to the production of recombinant protein therapies. We offer innovative clarification methods that separate based on charge, rather than particle size, removing large contaminants like cells and cell debris as well as smaller impurities like DNA and HCP.

Learn more about gene therapy
Medical Research Laboratory: Portrait of Female Scientist Working on Computer, Analysing DNA, Virus.

Plasma-derived therapies

Our products and solutions are used to create a range of life-saving therapies during plasma fractionation and purification—the critical process that involves separating various components of blood plasma. Solventum’s solutions are designed to meet your needs across a range of plasma-derived therapy manufacturing. 3M™ Zeta Plus™ Depth Filters are available in three formats: sheets, cartridges and capsules, with the right media and pore sizes to help you get the job done. 3M™ Zeta Plus™ Encapsulated System Filter Capsules can fulfil your depth filtration needs in an easy-to-use format.  

Sterile filtration is a critical step in the highly controlled environment of plasma processes. Our 3M™ LifeASSURE™ PDA Series Filter portfolio comes with advanced pleat technology to increase the effective filtration area.

Learn more about depth filtration used in plasma fractionation
Hands in blue medical gloves hold a tripod with test tubes containing blood samples. The blood has been divided into fractions. Blood plasma. In the background, there is a centrifuge.

Vaccine therapy

Managing purification and clarification as you scale your vaccine production can be complex while maintaining efficiency and yield. We provide a range of solutions that cater to your needs to improve clarification and desired purity and enable consistent product quality. Our 3M™ Harvest RC Chromatographic Clarifier platform and 3M™ Zeta Plus™ Encapsulated System Filter Capsules can be used from lab scale to commercial manufacturing, from discovery to production, to enable you to streamline processes and improve efficiency.

To learn more about our vaccine applications, reach out to one of our experts.

Ask an expert
Doctor administers vaccine

Chemical pharmaceuticals

Understanding the complexities of your chemical pharmaceutical manufacturing is important to us at Solventum. We provide you with filtration technologies for a wide range of applications including active pharmaceutical ingredient (API) manufacturing, across many stages of pharmaceutical processing and sterile filtration. Our membrane-based separations and depth filtration systems deliver optimal results to meet regulatory requirements.

Explore the 3M™ Zeta Plus™ Filter Cartridge with Activated Carbon Series Media Explore 3M™ LifeASSURE™ Membrane Filters (PDA, PNA, PLA, PFS) Explore 3M™ Zeta Plus™ Encapsulated System Filter Capsule with SP Series Media Explore 3M™ Betafine™ PPG Series Filter Cartridge
Photograph of a Sterile Pharmaceutical Manufacturing Laboratory where Scientists in Protective Coveralls Conduct Quality Control

Let our specialists help you achieve your vision

When you’re developing a new biopharmaceutical product, you want to focus on bringing your solution to patients — and that involves addressing challenges in research, development and manufacturing as soon as they arise. Our network of bioprocess application specialists can help you simplify your process and troubleshoot filtration issues, no matter where you are in your product journey or where you are located globally. With specialists in over 70 countries worldwide, we provide you with access to the best support so we can share ideas and learn from each other.

Ask an expert
Four smiling scientists look directly into the camera, three male, one female

Sustainability at Solventum

Solventum is prioritising sustainability in our operations, supply chain and corporate culture, including reducing our own greenhouse gas emissions, energy and water use, and waste. Our solutions are designed to help you meet your sustainability goals. As part of this commitment, our single-use technologies in biopharmaceutical manufacturing intensify the process, using fewer steps and inputs, which may result in a smaller environmental footprint than traditional, reusable methods. 

Solutions like the 3M™ Harvest RC Chromatographic Clarifier help combine the traditional 3-step clarification process into a single, intensified unit operation for chromatographic separation, lowering pre-use flush volumes and improving output through higher mAb product recovery. In turn, this reduces the amount of water and energy consumed in this phase, when compared to traditional clarification methods or stainless steel facility setups.

Learn more about sustainability with our solutionsopens in a new tab

Learn more about process intensificationopens in a new tab

As members of the Bio-Process Systems Allianceopens in a new tab, we share in their mission to facilitate the development and manufacturing of safe and sustainable single-use technologies. 

Process engineer in green lab coat looks at product

School of Purification: Start learning today

Developed by our global experts, passionate about innovative approaches to biopharmaceutical separation and purification, School of Purification provides resources to help you and your team get up to speed quickly. These free webinars and on-demand learning resources cover overcoming bottlenecks, optimising efficiency, current trends, and future possibilities.

Explore School of Purification
Photo of a smiling woman who is working from home

Next steps

Learn more about our products

Discover the full range of solutions that we can offer for your operation.

View products

Industry-leading news and resources

Explore our library of peer-reviewed articles, technical documents, brochures, and resources developed by our experts on trends and topics relevant to you and the industry.

Explore resources

Still have queries?

Our customer support specialists can help.

Find answers

Stay connected

Stay up to date with our products and educational resources.

Subscribe

Ask an expert

*All fields are required unless indicated optional

 

Solventum will use the informationto respond to your request and in accordance with our Privacy Policyopens in a new tab.

Not working

×